Cell Biology Antibodies 17
Anti-IRAK2 Antibody (CAB4655)
- SKU:
- CAB4655
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- IRAK-2
- Research Area:
- Cell Biology
Description
| Product Name: | IRAK2 Rabbit mAb |
| Product Code: | CAB4655 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | IRAK-2 |
| Applications: | WB, IHC |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human IRAK2 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | HeLa, HepG2, K-562 |
| Immunogen: | A synthesized peptide derived from human IRAK2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3656 |
| Uniprot: | O43187 |
| Calculated MW: | 69kDa |
| Observed MW: | 70KDa |
| UniProt Protein Function: | IRAK2: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; IRAK family Chromosomal Location of Human Ortholog: 3p25.3 Cellular Component: cytoplasm; cytosol; endosome membrane; nucleus; plasma membrane Molecular Function:protein binding; protein heterodimerization activity; protein homodimerization activity; protein serine/threonine kinase activity Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; I-kappaB kinase/NF-kappaB cascade; inflammatory response; inhibition of NF-kappaB transcription factor; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; protein amino acid phosphorylation; regulation of cytokine and chemokine mediated signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway |
| NCBI Summary: | IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43187 |
| NCBI GenInfo Identifier: | 125987833 |
| NCBI Gene ID: | 3656 |
| NCBI Accession: | O43187.2 |
| UniProt Secondary Accession: | O43187,Q08AG6, Q5K546, B4DQZ6, |
| UniProt Related Accession: | O43187 |
| Molecular Weight: | 69,433 Da |
| NCBI Full Name: | Interleukin-1 receptor-associated kinase-like 2 |
| NCBI Synonym Full Names: | interleukin 1 receptor associated kinase 2 |
| NCBI Official Symbol: | IRAK2 |
| NCBI Official Synonym Symbols: | IRAK-2 |
| NCBI Protein Information: | interleukin-1 receptor-associated kinase-like 2 |
| UniProt Protein Name: | Interleukin-1 receptor-associated kinase-like 2 |
| Protein Family: | Interleukin-1 receptor-associated kinase |
| UniProt Gene Name: | IRAK2 |
| UniProt Entry Name: | IRAK2_HUMAN |
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