Immunology Antibodies 3
Anti-IRAK1 Antibody (CAB4439)
- SKU:
- CAB4439
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- IRAK
- Synonyms:
- pelle
- Research Area:
- Immunology
Description
| Product Name: | IRAK1 Rabbit mAb |
| Product Code: | CAB4439 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | IRAK, pelle |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human IRAK1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa |
| Immunogen: | A synthesized peptide derived from human IRAK1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3654 |
| Uniprot: | P51617 |
| Calculated MW: | 77kDa |
| Observed MW: | 78KDa |
| UniProt Protein Function: | IRAK1: a TKL kinase of the IRAK family. Involved in Toll/IL-1 signaling. One of two putative serine/threonine kinases that become associated with the interleukin-1 receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Extensively phosphorylated after its association with IL1-R-1. Polyubiquitinated; after cell stimulation with IL-1-beta. Polyubiquitination occurs with polyubiquitin chains linked through 'Lys-63'. Partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Three isoforms of the human protein and produced by alternative splicing. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1. Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2. |
| UniProt Protein Details: | Protein type:Protein kinase, TKL; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; IRAK family Chromosomal Location of Human Ortholog: Xq28 Cellular Component: cytoplasm; cytosol; endosome membrane; lipid particle; nucleus; plasma membrane Molecular Function:kinase activity; NF-kappaB-inducing kinase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; inhibition of NF-kappaB transcription factor; JNK cascade; lipopolysaccharide-mediated signaling pathway; MyD88-dependent toll-like receptor signaling pathway; negative regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon type I production; positive regulation of MAP kinase activity; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein oligomerization; regulation of cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway |
| NCBI Summary: | This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51617 |
| NCBI GenInfo Identifier: | 8928535 |
| NCBI Gene ID: | 3654 |
| NCBI Accession: | P51617.2 |
| UniProt Secondary Accession: | P51617,Q7Z5V4, Q96C06, Q96RL2, D3DWW3, D3DWW4, |
| UniProt Related Accession: | P51617 |
| Molecular Weight: | 68,022 Da |
| NCBI Full Name: | Interleukin-1 receptor-associated kinase 1 |
| NCBI Synonym Full Names: | interleukin 1 receptor associated kinase 1 |
| NCBI Official Symbol: | IRAK1 |
| NCBI Official Synonym Symbols: | IRAK; pelle |
| NCBI Protein Information: | interleukin-1 receptor-associated kinase 1 |
| UniProt Protein Name: | Interleukin-1 receptor-associated kinase 1 |
| Protein Family: | Interleukin-1 receptor-associated kinase |
| UniProt Gene Name: | IRAK1 |
| UniProt Entry Name: | IRAK1_HUMAN |
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