Signal Transduction Antibodies 1

Anti-IQWD1 Antibody (CAB14286)

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SKU:
CAB14286
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-IQWD1 Antibody
Antibody SKU:CAB14286
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 460-650 of human IQWD1 (NP_001017977.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, LO2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 460-650 of human IQWD1 (NP_001017977.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DNNN EKLS PKPG TGEP VLSL HYST EGTT TSTI KLNF TDEW SSIA SSSR GIGS HCKS EGQE ESFV PQSS VQPP EGDS ETKA PEES SEDV TKYQ EGVS AENP VENH INIT QSDK FTAK PLDS NSGE RNDL NLDR SCGV PEES ASSE KAKE PETS DQTS TESA TNEN NTNP EPQF QTEA TGPS AHEE TSTR DSA
Gene ID:55827
Uniprot:Q58WW2
Cellular Location:Nucleus
Calculated MW:96kDa/98kDa/103kDa/106kDa
Observed MW:105kDa
Synonyms:DCAF6, 1200006M05Rik, ARCAP, IQWD1, MSTP055, NRIP, PC326
Background:The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression.
UniProt Protein Function:MSTP055: Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: nucleoplasm; focal adhesion; cytoplasm; nucleus

Molecular Function:ligand-dependent nuclear receptor transcription coactivator activity

Biological Process: protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter

UniProt Code:Q58WW2
NCBI GenInfo Identifier:74755134
NCBI Gene ID:55827
NCBI Accession:Q58WW2.1
UniProt Secondary Accession:Q58WW2,Q7L8I0, Q8IXH3, Q8TB19, A2A295, B4DNB8,
UniProt Related Accession:Q58WW2
Molecular Weight:103,070 Da
NCBI Full Name:DDB1- and CUL4-associated factor 6
NCBI Synonym Full Names:DDB1 and CUL4 associated factor 6
NCBI Official Symbol:DCAF6  
NCBI Official Synonym Symbols:NRIP; ARCAP; IQWD1; PC326; MSTP055; 1200006M05Rik  
NCBI Protein Information:DDB1- and CUL4-associated factor 6; IQ motif and WD repeat-containing protein 1; IQ motif and WD repeats 1; androgen receptor complex-associated protein; nuclear receptor interaction protein
UniProt Protein Name:DDB1- and CUL4-associated factor 6
UniProt Synonym Protein Names:Androgen receptor complex-associated protein; ARCAP; IQ motif and WD repeat-containing protein 1; Nuclear receptor interaction protein; NRIP
Protein Family:DDB1- and CUL4-associated factor
UniProt Gene Name:DCAF6  
UniProt Entry Name:DCAF6_HUMAN
Anti-IQWD1 Antibody (CAB14286)Western blot analysis of extracts of various cell lines, using IQWD1 antibody (CAB14286) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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