Cell Biology Antibodies 7
Anti-IQSEC1 Antibody (CAB16725)
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- SKU:
- CAB16725
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-IQSEC1 Antibody |
| Antibody SKU: | CAB16725 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human IQSEC1 (NP_055684.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | mouse brain, rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human IQSEC1 (NP_055684.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SFEG PEKV HSSY FEGK QVSV TNDG SQLG ALVS PECG DLSE PTTL KSPA PSSD FADA ITEL EDAF SRQV KSLA ESID DALN CRSL HTEE APAL DAAR ARDT EPQT ALHG MDHR KLDE MTAS YSDV TLYI DEEE LSPP LPLS QAGD RPSS TESD LRLR AGGA APDY WALA HKED KADT DTSC RSTP SLER QEQR LRVE HLPL L |
| Gene ID: | 9922 |
| Uniprot: | Q6DN90 |
| Cellular Location: | |
| Calculated MW: | 108kDa |
| Observed MW: | 108kDa |
| Synonyms: | IQSEC1, ARF-GEP100, ARFGEP100, BRAG2, GEP100 |
| Background: |
| UniProt Protein Function: | IQSEC1: In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. Belongs to the BRAG family. Interacts with ARF6. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs, ARF; Motility/polarity/chemotaxis; GAPs Chromosomal Location of Human Ortholog: 3p25.2 Cellular Component: membrane Biological Process: actin cytoskeleton organization and biogenesis |
| UniProt Code: | Q6DN90 |
| NCBI GenInfo Identifier: | 16307438 |
| NCBI Gene ID: | 9922 |
| NCBI Accession: | BC010267 |
| UniProt Secondary Accession: | Q6DN90,O94863, Q96D85, |
| UniProt Related Accession: | Q6DN90 |
| Molecular Weight: | 94,914 Da |
| NCBI Full Name: | Homo sapiens IQ motif and Sec7 domain 1, mRNA |
| NCBI Synonym Full Names: | IQ motif and Sec7 domain 1 |
| NCBI Official Symbol: | IQSEC1 |
| NCBI Official Synonym Symbols: | BRAG2; GEP100; ARFGEP100; ARF-GEP100 |
| NCBI Protein Information: | IQ motif and SEC7 domain-containing protein 1 |
| UniProt Protein Name: | IQ motif and SEC7 domain-containing protein 1 |
| UniProt Synonym Protein Names: | ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; Brefeldin-resistant Arf-GEF 2 protein |
| Protein Family: | IQ motif and SEC7 domain-containing protein |
| UniProt Gene Name: | IQSEC1 |
| UniProt Entry Name: | IQEC1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IQSEC1 antibody (CAB16725) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min. |
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