Cell Biology Antibodies 10

Anti-INTS5 Antibody (CAB6633)

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SKU:
CAB6633
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-INTS5 Antibody
Antibody SKU:CAB6633
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human INTS5 (NP_085131.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, MCF7, U-937, HT-29, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human INTS5 (NP_085131.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DVVQ EVQQ VLSE FIRA NPKA WAPV ISAW SIDL MGQL SSTY SGQH QRVP HATG ALNE LLQL WMGC RATR TLMD IYVQ CLSA LIGS CPDA CVDA LLDT SVQH SPHF DWVV AHIG SSFP GTII SRVL SCGL KDFC VHGG AGGG AGSS GGSS SQTP STDP FPGS PAIP AEKR VPKI ASVV GILG HLAS RHGD SIRR ELLR MFHD SLAG GSGG RSGD PSLQ ATVP FLLQ LAVM SPAL LGTV SGEL VDCL KPPA VLSQ LQQH LQGF PREE LDNM LNLA VHLV SQAS G
Gene ID:80789
Uniprot:Q6P9B9
Cellular Location:Membrane, Multi-pass membrane protein, Nucleus
Calculated MW:107kDa
Observed MW:109kDa
Synonyms:INTS5, INT5, KIAA1698
Background:The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex.
UniProt Protein Function:INTS5: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
UniProt Protein Details:

Protein type:RNA processing; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q12.3

Cellular Component: membrane; integral to membrane; nucleus; integrator complex

Molecular Function:protein binding

Biological Process: snRNA processing

NCBI Summary:The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016]
UniProt Code:Q6P9B9
NCBI GenInfo Identifier:74737528
NCBI Gene ID:80789
NCBI Accession:Q6P9B9.1
UniProt Related Accession:Q6P9B9
Molecular Weight:107kDa
NCBI Full Name:Integrator complex subunit 5
NCBI Synonym Full Names:integrator complex subunit 5
NCBI Official Symbol:INTS5  
NCBI Official Synonym Symbols:INT5; KIAA1698  
NCBI Protein Information:integrator complex subunit 5
UniProt Protein Name:Integrator complex subunit 5
Protein Family:Integrator complex
UniProt Gene Name:INTS5  
UniProt Entry Name:INT5_HUMAN
Anti-INTS5 Antibody (CAB6633)Western blot analysis of extracts of various cell lines, using INTS5 antibody (CAB6633) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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