Cell Biology Antibodies 10
Anti-INTS10 Antibody (CAB6632)
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- SKU:
- CAB6632
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-INTS10 Antibody |
| Antibody SKU: | CAB6632 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 451-710 of human INTS10 (NP_060612.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, HL-60, HepG2, THP-1, Mouse kidney, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 451-710 of human INTS10 (NP_060612.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FLTD MIIY QGQY KKAI ASLH HLAA LQGS ISQP QITG QGTL EHQR ALIQ LATC HFAL GEYR MTCE KVLD LMCY MVLP IQDG GKSQ EEPS KVKP KFRK GSDL KLLP CTSK AIMP YCLH LMLA CFKL RAFT DNRD DMAL GHVI VLLQ QEWP RGEN LFLK AVNK ICQQ GNFQ YENF FNYV TNID MLEE FAYL RTQE GGKI HLEL LPNQ GMLI KHHT VTRG ITKG VKED FRLA MERQ VSRC GENL MVVL HRFC INEK ILLL QTLT |
| Gene ID: | 55174 |
| Uniprot: | Q9NVR2 |
| Cellular Location: | Nucleus |
| Calculated MW: | 82kDa |
| Observed MW: | 70-75kDa |
| Synonyms: | INTS10, C8orf35, INT10 |
| Background: |
| UniProt Protein Function: | INTS10: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Belongs to the Integrator subunit 10 family. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 8p21.3 Cellular Component: integrator complex Molecular Function:protein binding Biological Process: snRNA processing |
| NCBI Summary: | INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9NVR2 |
| NCBI GenInfo Identifier: | 97052274 |
| NCBI Gene ID: | 55174 |
| NCBI Accession: | Q9NVR2.2 |
| UniProt Secondary Accession: | Q9NVR2,Q6IA93, Q7L538, Q7L8C8, Q9H3W8, |
| UniProt Related Accession: | Q9NVR2 |
| Molecular Weight: | 710 |
| NCBI Full Name: | Integrator complex subunit 10 |
| NCBI Synonym Full Names: | integrator complex subunit 10 |
| NCBI Official Symbol: | INTS10 |
| NCBI Official Synonym Symbols: | INT10; C8orf35 |
| NCBI Protein Information: | integrator complex subunit 10 |
| UniProt Protein Name: | Integrator complex subunit 10 |
| Protein Family: | Integrator complex |
| UniProt Gene Name: | INTS10 |
| UniProt Entry Name: | INT10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using INTS10 antibody (CAB6632) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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