Cell Biology Antibodies 12
Anti-Integrin beta-8 Antibody (CAB8433)
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- SKU:
- CAB8433
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Integrin beta-8 Antibody |
| Antibody SKU: | CAB8433 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 43-320 of human ITGB8 (NP_002205.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SGC-7901, 293T, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 43-320 of human ITGB8 (NP_002205.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EDNR CASS NAAS CARC LALG PECG WCVQ EDFI SGGS RSER CDIV SNLI SKGC SVDS IEYP SVHV IIPT ENEI NTQV TPGE VSIQ LRPG AEAN FMLK VHPL KKYP VDLY YLVD VSAS MHNN IEKL NSVG NDLS RKMA FFSR DFRL GFGS YVDK TVSP YISI HPER IHNQ CSDY NLDC MPPH GYIH VLSL TENI TEFE KAVH RQKI SGNI DTPE GGFD AMLQ AAVC ESHI GWRK EAKR LLLV MTDQ TSHL ALDS KLAG IVVP NDGN CHLK NNVY VKST TM |
| Gene ID: | 3696 |
| Uniprot: | P26012 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 71kDa/85kDa |
| Observed MW: | 100kDa |
| Synonyms: | ITGB8 |
| Background: | This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
| UniProt Protein Function: | ITGB8: Integrin alpha-V/beta-8 is a receptor for fibronectin. Belongs to the integrin beta chain family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7p21.1 Cellular Component: cell surface; integrin complex; plasma membrane Biological Process: cartilage development; cell adhesion; cell-matrix adhesion; extracellular matrix organization and biogenesis |
| NCBI Summary: | This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P26012 |
| NCBI GenInfo Identifier: | 124975 |
| NCBI Gene ID: | 3696 |
| NCBI Accession: | P26012.1 |
| UniProt Secondary Accession: | P26012,A4D133, B4DHD4, |
| UniProt Related Accession: | P26012 |
| Molecular Weight: | 71,284 Da |
| NCBI Full Name: | Integrin beta-8 |
| NCBI Synonym Full Names: | integrin subunit beta 8 |
| NCBI Official Symbol: | ITGB8 |
| NCBI Protein Information: | integrin beta-8 |
| UniProt Protein Name: | Integrin beta-8 |
| Protein Family: | Integrin |
| UniProt Gene Name: | ITGB8 |
| UniProt Entry Name: | ITB8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ITGB8 antibody (CAB8433) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded rat brain using ITGB8 antibody (CAB8433) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using ITGB8 antibody (CAB8433) at dilution of 1:100 (40x lens). |
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