Antibody Name:	Anti-Integrin beta-8 Antibody
Antibody SKU:	CAB8433
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 43-320 of human ITGB8 (NP_002205.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	SGC-7901, 293T, HeLa

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 43-320 of human ITGB8 (NP_002205.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	EDNR CASS NAAS CARC LALG PECG WCVQ EDFI SGGS RSER CDIV SNLI SKGC SVDS IEYP SVHV IIPT ENEI NTQV TPGE VSIQ LRPG AEAN FMLK VHPL KKYP VDLY YLVD VSAS MHNN IEKL NSVG NDLS RKMA FFSR DFRL GFGS YVDK TVSP YISI HPER IHNQ CSDY NLDC MPPH GYIH VLSL TENI TEFE KAVH RQKI SGNI DTPE GGFD AMLQ AAVC ESHI GWRK EAKR LLLV MTDQ TSHL ALDS KLAG IVVP NDGN CHLK NNVY VKST TM
Gene ID:	3696
Uniprot:	P26012
Cellular Location:	Membrane, Single-pass type I membrane protein
Calculated MW:	71kDa/85kDa
Observed MW:	100kDa

Synonyms:

ITGB8

Background:

This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

UniProt Protein Function:	ITGB8: Integrin alpha-V/beta-8 is a receptor for fibronectin. Belongs to the integrin beta chain family.
UniProt Protein Details:	Protein type:Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7p21.1 Cellular Component: cell surface; integrin complex; plasma membrane Biological Process: cartilage development; cell adhesion; cell-matrix adhesion; extracellular matrix organization and biogenesis
NCBI Summary:	This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Code:	P26012
NCBI GenInfo Identifier:	124975
NCBI Gene ID:	3696
NCBI Accession:	P26012.1
UniProt Secondary Accession:	P26012,A4D133, B4DHD4,
UniProt Related Accession:	P26012
Molecular Weight:	71,284 Da
NCBI Full Name:	Integrin beta-8
NCBI Synonym Full Names:	integrin subunit beta 8
NCBI Official Symbol:	ITGB8
NCBI Protein Information:	integrin beta-8
UniProt Protein Name:	Integrin beta-8
Protein Family:	Integrin
UniProt Gene Name:	ITGB8
UniProt Entry Name:	ITB8_HUMAN

	Western blot analysis of extracts of various cell lines, using ITGB8 antibody (CAB8433) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
	Immunohistochemistry of paraffin-embedded rat brain using ITGB8 antibody (CAB8433) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse brain using ITGB8 antibody (CAB8433) at dilution of 1:100 (40x lens).