Cell Biology Antibodies 17
Anti-Integrin beta 4 Antibody (CAB4596)
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- SKU:
- CAB4596
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Integrin beta 4 Antibody |
| Antibody SKU: | CAB4596 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Integrin beta 4 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, A-549, Mouse brain |
| Immunogen: | A synthesized peptide derived from human Integrin beta 4 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3691 |
| Uniprot: | P16144 |
| Cellular Location: | |
| Calculated MW: | 210kDa |
| Observed MW: | 210KDa |
| Synonyms: | CD104, GP150 |
| Background: | Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | ITGB4: integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Five alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 17q25 Cellular Component: cell surface; hemidesmosome; leading edge; plasma membrane; basal plasma membrane; basement membrane; integrin complex; receptor complex Molecular Function:protein binding; G-protein-coupled receptor binding; receptor activity Biological Process: skin development; integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; hemidesmosome assembly; filopodium formation; gut development; cell-matrix adhesion; cell motility involved in cell locomotion; response to wounding; mesodermal cell differentiation; autophagy; cell adhesion Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type; Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Junctionalis With Pyloric Atresia |
| NCBI Summary: | Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P16144 |
| NCBI GenInfo Identifier: | 317373584 |
| NCBI Gene ID: | 3691 |
| NCBI Accession: | P16144.5 |
| UniProt Secondary Accession: | P16144,O14690, O14691, O15339, O15340, O15341, Q0VF97 Q9UIQ4, A0AVL6, |
| UniProt Related Accession: | P16144 |
| Molecular Weight: | 106,779 Da |
| NCBI Full Name: | Integrin beta-4 |
| NCBI Synonym Full Names: | integrin, beta 4 |
| NCBI Official Symbol: | ITGB4 |
| NCBI Official Synonym Symbols: | CD104 |
| NCBI Protein Information: | integrin beta-4; GP150; CD104 antigen; integrin beta-4 subunit |
| UniProt Protein Name: | Integrin beta-4 |
| UniProt Synonym Protein Names: | GP150; CD_antigen: CD104 |
| Protein Family: | Integrin |
| UniProt Gene Name: | ITGB4 |
| UniProt Entry Name: | ITB4_HUMAN |
 | Western blot - Integrin beta 4 Rabbit mAb (CAB4596) |
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