Cell Biology Antibodies 12
Anti-Integrin alpha-E Antibody (CAB9934)
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- SKU:
- CAB9934
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Integrin alpha-E Antibody |
| Antibody SKU: | CAB9934 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-200 of human ITGAE (NP_002199.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, SW620, HeLa, Mouse lung, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-200 of human ITGAE (NP_002199.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FNVD VARP WLTP KGGA PFVL SSLL HQDP STNQ TWLL VTSP RTKR TPGP LHRC SLVQ DEIL CHPV EHVP IPKG RHRG VTVV RSHH GVLI CIQV LVRR PHSL SSEL TGTC SLLG PDLR PQAQ ANFF DLEN LLDP DARV DTGD CYSN KEGG GEDD VNTA RQRR ALEK EEEE DKEE EEDE EEEE AG |
| Gene ID: | 3682 |
| Uniprot: | P38570 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 130kDa |
| Observed MW: | 110kDa |
| Synonyms: | ITGAE, CD103, HUMINAE |
| Background: | Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. |
| UniProt Protein Function: | ITGAE: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Belongs to the integrin alpha chain family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 17p13 Cellular Component: plasma membrane; integrin complex; external side of plasma membrane Molecular Function:metal ion binding Biological Process: integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; cell adhesion |
| NCBI Summary: | Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P38570 |
| NCBI GenInfo Identifier: | 226694184 |
| NCBI Gene ID: | 3682 |
| NCBI Accession: | P38570.3 |
| UniProt Secondary Accession: | P38570,Q17RS6, Q9NZU9, |
| UniProt Related Accession: | P38570 |
| Molecular Weight: | 130,159 Da |
| NCBI Full Name: | Integrin alpha-E |
| NCBI Synonym Full Names: | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
| NCBI Official Symbol: | ITGAE |
| NCBI Official Synonym Symbols: | CD103; HUMINAE |
| NCBI Protein Information: | integrin alpha-E; HML-1 antigen; integrin alpha-IEL; mucosal lymphocyte 1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide |
| UniProt Protein Name: | Integrin alpha-E |
| UniProt Synonym Protein Names: | HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD_antigen: CD103Cleaved into the following 2 chains:Integrin alpha-E light chain; Integrin alpha-E heavy chain |
| Protein Family: | Integrin |
| UniProt Gene Name: | ITGAE |
| UniProt Entry Name: | ITAE_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ITGAE antibody (CAB9934) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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