Anti-Integrin alpha 6 (ITGA6/CD49f) Antibody (CAB20807)
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- SKU:
- CAB20807
Description
| Antibody Name: | Anti-Integrin alpha 6 (ITGA6/CD49f) Antibody (CAB20807) |
| Antibody SKU: | CAB20807 |
| Antibody Size: | 50µL, 100µL |
| Application: | Western blotting |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 481-591 of human Integrin alpha 6 (ITGA6/CD49f) (NP_001073286.1). |
| Application: | Western blotting |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | PC-3, U-251MG, Mouse lung, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 481-591 of human Integrin alpha 6 (ITGA6/CD49f) (NP_001073286.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IDLR QKTA CGAP SGIC LQVK SCFE YTAN PAGY NPSI SIVG TLEA EKER RKSG LSSR VQFR NQGS EPKY TQEL TLKR QKQK VCME ETLW LQDN IRDK LRPI PITA SVEI QEP |
| Cellular Location: | Cell membrane, Lipid-anchor, Single-pass type I membrane protein |
| Calculated MW: | 106kDa/119kDa/121kDa/122kDa/124kDa/126kDa |
| Observed MW: | 125KDa |
| Synonyms: | CD49f, ITGA6B, VLA-6, Integrin alpha 6, ITGA6 |
| Background: | The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. |
 | Western blot analysis of extracts of various cell lines, using Integrin alpha 6 (ITGA6/CD49f) antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s. |
 | Western blot analysis of extracts of various cell lines, using Integrin alpha 6 (ITGA6/CD49f) antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s. |
Additional Information
Product Type: |
Antibody |
Antibody Type: |
Secondary Antibody |
Host Species: |
Goat |
Isotype: |
IgG |
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