Cell Biology Antibodies 17
Anti-Integrin alpha 2 Antibody (CAB19068)
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- SKU:
- CAB19068
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Integrin alpha 2 Antibody |
| Antibody SKU: | CAB19068 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Integrin alpha 2 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse lung, Mouse large intestine, Mouse spleen, Rat lung, A-549 |
| Immunogen: | A synthesized peptide derived from human Integrin alpha 2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3673 |
| Uniprot: | P17301 |
| Cellular Location: | |
| Calculated MW: | 150kDa |
| Observed MW: | 150kDa |
 | Western blot - Integrin alpha 2 Rabbit mAb (CAB19068) |
| Synonyms: | BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, ITGA2 |
| Background: | This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
| UniProt Protein Function: | ITGA2: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Belongs to the integrin alpha chain family. |
| UniProt Protein Details: | Protein type:Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 5q11.2 Cellular Component: cell surface; focal adhesion; integrin complex; plasma membrane Molecular Function:collagen binding; protein binding; protein complex binding Biological Process: blood coagulation; cell adhesion; cell adhesion mediated by integrin; cell-matrix adhesion; cell-substrate adhesion; extracellular matrix organization and biogenesis; integrin-mediated signaling pathway; mesodermal cell differentiation; organ morphogenesis; substrate-bound cell migration Disease: Bleeding Disorder, Platelet-type, 9 |
| NCBI Summary: | This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
| UniProt Code: | P17301 |
| NCBI GenInfo Identifier: | 124942 |
| NCBI Gene ID: | 3673 |
| NCBI Accession: | P17301.1 |
| UniProt Secondary Accession: | P17301,Q14595, |
| UniProt Related Accession: | P17301 |
| Molecular Weight: | 129,295 Da |
| NCBI Full Name: | Integrin alpha-2 |
| NCBI Synonym Full Names: | integrin subunit alpha 2 |
| NCBI Official Symbol: | ITGA2 |
| NCBI Official Synonym Symbols: | BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2 |
| NCBI Protein Information: | integrin alpha-2 |
| UniProt Protein Name: | Integrin alpha-2 |
| UniProt Synonym Protein Names: | CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD_antigen: CD49b |
| Protein Family: | Integrin |
| UniProt Gene Name: | ITGA2 |
| UniProt Entry Name: | ITA2_HUMAN |
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