Cell Biology Antibodies 1

Anti-INSRR Antibody (CAB10083)

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SKU:
CAB10083
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-INSRR Antibody
Antibody SKU:CAB10083
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 747-921 of human INSRR (NP_055030.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Mouse liver, Mouse kidney, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 747-921 of human INSRR (NP_055030.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AAGP LRLG GNSS DFEI QEDK VPRE RAVL SGLR HFTE YRID IHAC NHAA HTVG CSAA TFVF ARTM PHRE ADGI PGKV AWEA SSKN SVLL RWLE PPDP NGLI LKYE IKYR RLGE EATV LCVS RLRY AKFG GVHL ALLP PGNY SARV RATS LAGN GSWT DSVA FYIL GPEE EDAG GLH
Gene ID:3645
Uniprot:P14616
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:143kDa
Observed MW:105kDa
Synonyms:INSRR, IRR
Background:
UniProt Protein Function:IRR: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
UniProt Protein Details:

Protein type:Protein kinase, TK; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; InsR family

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: integral to plasma membrane; receptor complex

Molecular Function:insulin receptor substrate binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; male sex determination; actin cytoskeleton reorganization; transmembrane receptor protein tyrosine kinase signaling pathway

UniProt Code:P14616
NCBI GenInfo Identifier:31657140
NCBI Gene ID:3645
NCBI Accession:NP_055030.1
UniProt Secondary Accession:P14616,O60724, Q5VZS3,
UniProt Related Accession:P14616
Molecular Weight:143,720 Da
NCBI Full Name:insulin receptor-related protein
NCBI Synonym Full Names:insulin receptor-related receptor
NCBI Official Symbol:INSRR  
NCBI Official Synonym Symbols:IRR  
NCBI Protein Information:insulin receptor-related protein; IR-related receptor
UniProt Protein Name:Insulin receptor-related protein
UniProt Synonym Protein Names:IR-related receptor
Protein Family:Insulin receptor-related protein
UniProt Gene Name:INSRR  
UniProt Entry Name:INSRR_HUMAN
Anti-INSRR Antibody (CAB10083)Western blot analysis of extracts of various cell lines, using INSRR antibody (CAB10083) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s.
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