Cell Biology Antibodies 9
Anti-INSL3 Antibody (CAB5728)
(No reviews yet)
Write a Review
- SKU:
- CAB5728
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-INSL3 Antibody |
| Antibody SKU: | CAB5728 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-131 of human INSL3 (NP_005534.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-937 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-131 of human INSL3 (NP_005534.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDPR LPAW ALVL LGPA LVFA LGPA PTPE MREK LCGH HFVR ALVR VCGG PRWS TEAR RPAT GGDR ELLQ WLER RHLL HGLV ADSN LTLG PGLQ PLPQ TSHH HRHH RAAA TNPA RYCC LSGC TQQD LLTL CPY |
| Gene ID: | 3640 |
| Uniprot: | P51460 |
| Cellular Location: | Secreted |
| Calculated MW: | 14kDa/16kDa |
| Observed MW: | 15kDa |
| Synonyms: | INSL3, RLF, RLNL, ley-I-L |
| Background: | This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | INSL3: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. Defects in INSL3 seems to be a cause of cryptorchidism (CRYPTO); also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. The frequency of INSL3 gene mutations as a cause of cryptorchidism is low. Belongs to the insulin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19p13.2-p12 Cellular Component: extracellular space; perinuclear region of cytoplasm; extracellular region Molecular Function:G-protein-coupled receptor binding; protease binding; hormone activity; insulin receptor binding; receptor binding Biological Process: negative regulation of cell proliferation; cell-cell signaling; in utero embryonic development; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; male gonad development; spermatogenesis; G-protein signaling, adenylate cyclase inhibiting pathway; oocyte maturation; negative regulation of apoptosis Disease: Cryptorchidism, Unilateral Or Bilateral |
| NCBI Summary: | This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012] |
| UniProt Code: | P51460 |
| NCBI GenInfo Identifier: | 317373369 |
| NCBI Gene ID: | 3640 |
| NCBI Accession: | P51460.2 |
| UniProt Secondary Accession: | P51460,Q3KPI5, Q3KPI6, Q6YNB5, Q9UEA2, Q9UPH6, B4DZ72 G3XAG0, |
| UniProt Related Accession: | P51460 |
| Molecular Weight: | 16,872 Da |
| NCBI Full Name: | Insulin-like 3 |
| NCBI Synonym Full Names: | insulin-like 3 (Leydig cell) |
| NCBI Official Symbol: | INSL3 |
| NCBI Official Synonym Symbols: | RLF; RLNL; ley-I-L |
| NCBI Protein Information: | insulin-like 3; prepro-INSL3; relaxin-like factor b; leydig insulin-like peptide; leydig insulin -like hormone |
| UniProt Protein Name: | Insulin-like 3 |
| UniProt Synonym Protein Names: | Leydig insulin-like peptide; Ley-I-L; Relaxin-like factorCleaved into the following 2 chains:Insulin-like 3 B chain; Insulin-like 3 A chain |
| Protein Family: | Insulin |
| UniProt Gene Name: | INSL3 |
| UniProt Entry Name: | INSL3_HUMAN |
 | Western blot analysis of extracts of U-937 cells, using INSL3 antibody (CAB5728) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human prostate using INSL3 antibody (CAB5728) at dilution of 1:100 (40x lens). |
View AllClose
Related Products
Human INSL3 Recombinant Protein (RPES3589)
system_update_altDatasheetHuman INSL3 Recombinant Protein Insulin-like 3 is a protein that in humans is encoded by the INSL3 gene. It is a secreted protein that belongs to the insulin family. It
