Cell Biology Antibodies 8

Anti-INPP5A Antibody (CAB3302)

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SKU:
CAB3302
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-INPP5A Antibody
Antibody SKU:CAB3302
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 10-200 of human INPP5A (NP_005530.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse heart, Mouse lung, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 10-200 of human INPP5A (NP_005530.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TAVL LVTA NVGS LFDD PENL QKNW LREF YQVV HTHK PHFM ALHC QEFG GKNY EASM SHVD KFVK ELLS SDAM KEYN RARV YLDE NYKS QEHF TALG SFYF LHES LKNI YQFD FKAK KYRK VAGK EIYS DTLE STPM LEKE KFPQ DYFP ECKW SRKG FIRT RWCI ADCA FDLV NIHL FHDA SNLV AWET SPS
Gene ID:3632
Uniprot:Q14642
Cellular Location:Lipid-anchor, Membrane
Calculated MW:47kDa
Observed MW:40kDa
Synonyms:INPP5A, 5PTASE
Background:The protein encoded by this gene is a membrane-associated type I inositol 1, 4, 5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1, 4, 5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.
UniProt Protein Function:INPP5A: Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction. Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type I family.
UniProt Protein Details:

Protein type:Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.56; Phosphatase (non-protein)

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: plasma membrane

Molecular Function:PH domain binding; protein binding

Biological Process: inositol phosphate metabolic process

NCBI Summary:The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]
UniProt Code:Q14642
NCBI GenInfo Identifier:3122245
NCBI Gene ID:3632
NCBI Accession:Q14642.1
UniProt Secondary Accession:Q14642,Q14640, Q5JSF1, D3DXI3,
UniProt Related Accession:Q14642
Molecular Weight:47,820 Da
NCBI Full Name:Type I inositol 1,4,5-trisphosphate 5-phosphatase
NCBI Synonym Full Names:inositol polyphosphate-5-phosphatase A
NCBI Official Symbol:INPP5A  
NCBI Official Synonym Symbols:5PTASE  
NCBI Protein Information:type I inositol 1,4,5-trisphosphate 5-phosphatase
UniProt Protein Name:Type I inositol 1,4,5-trisphosphate 5-phosphatase
Protein Family:Type I inositol 1,4,5-trisphosphate 5-phosphatase
UniProt Gene Name:INPP5A  
UniProt Entry Name:I5P1_HUMAN
Anti-INPP5A Antibody (CAB3302)Western blot analysis of extracts of various cell lines, using INPP5A antibody (CAB3302) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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