Signal Transduction Antibodies 2

Anti-INPP4B Antibody (CAB16461)

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SKU:
CAB16461
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-INPP4B Antibody
Antibody SKU:CAB16461
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 380-600 of human INPP4B (NP_003857.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, A375
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 380-600 of human INPP4B (NP_003857.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GLRK LLHR FETE RRNT GYQF IYYS PENT AKAK EVLS NINQ LQPL IATH ADLL LNSA SQHS PDSL KNSL KMLS EKTE LFVH AFKD QLVR SALL ALYT ARPG GILK KPPS PKSS TEES SPQD QPPV MRGQ DSIP HHSD YDEE EWDR VWAN VGKS LNCI IAMV DKLI ERDG GSEG SGGN NDGE KEPS LTDA IPSH PRED WYEQ LYPL ILTL KDCM GEVV NRAK Q
Gene ID:8821
Uniprot:O15327
Cellular Location:
Calculated MW:14kDa/104kDa
Observed MW:98kDa
Synonyms:INPP4B
Background:INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3, 4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme.
UniProt Protein Function:INPP4B: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate. Widely expressed with highest levels occurring in the skeletal muscle and heart. Strongly inhibited by inositol hexakisphosphate. Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.66; Phosphatase, lipid

Chromosomal Location of Human Ortholog: 4q31.21

Cellular Component: cytoplasm; cytosol

Molecular Function:inositol-1,3,4-trisphosphate 4-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; protein binding

Biological Process: inositol phosphate metabolic process; phosphatidylinositol biosynthetic process; signal transduction

NCBI Summary:INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
UniProt Code:O15327
NCBI GenInfo Identifier:218512158
NCBI Gene ID:8821
NCBI Accession:O15327.4
UniProt Secondary Accession:O15327,Q2TAI2, Q5XLE7, Q6IN59, Q6PJB4,
UniProt Related Accession:O15327
Molecular Weight:14,740 Da
NCBI Full Name:Type II inositol 3,4-bisphosphate 4-phosphatase
NCBI Synonym Full Names:inositol polyphosphate-4-phosphatase type II B
NCBI Official Symbol:INPP4B  
NCBI Protein Information:type II inositol 3,4-bisphosphate 4-phosphatase
UniProt Protein Name:Type II inositol 3,4-bisphosphate 4-phosphatase
UniProt Synonym Protein Names:Inositol polyphosphate 4-phosphatase type II
Protein Family:Type II inositol 3,4-bisphosphate 4-phosphatase
UniProt Gene Name:INPP4B  
UniProt Entry Name:INP4B_HUMAN
Anti-INPP4B Antibody (CAB16461)Western blot analysis of extracts of various cell lines, using INPP4B antibody (CAB16461) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 150s.
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