Cell Biology Antibodies 11

Anti-INPP4A Antibody (CAB7691)

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SKU:
CAB7691
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-INPP4A Antibody
Antibody SKU:CAB7691
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human INPP4A (NP_004018.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, MCF7, 293T, Mouse testis, Mouse skeletal muscle, Rat skeletal muscle
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human INPP4A (NP_004018.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTAR EHSP RHGA RARA MQRA STID VAAD MLGL SLAG NIQD PDEP ILEF SLAC SELH TPSL DRKP NSFV AVSV TTPP QAFW TKHA QTEI IEGT NNPI FLSS IAFF QDSL INQM TQVK LSVY DVKD RSQG TMYL LGSG TFIV KDLL QDRH HRLH LTLR SAES DRVG NITV IGWQ MEEK SDQR PPVT RSVD TVNG RMVL PVDE SLTE ALGI RSKY ASLR KDTL LKSV FGGA ICRM YRFP TTDG NHLR ILEQ MA
Gene ID:3631
Uniprot:Q96PE3
Cellular Location:
Calculated MW:105kDa/107kDa/109kDa
Observed MW:100kDa
Synonyms:INPP4A, INPP4, TVAS1
Background:This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3, 4-bisphosphate, inositol 1, 3, 4-trisphosphate, and inositol 3, 4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described.
UniProt Protein Function:INPP4: inositol polyphosphate 4-phosphatase type I, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate.
UniProt Protein Details:

Protein type:Phosphatase, lipid; EC 3.1.3.66; Carbohydrate Metabolism - inositol phosphate

Chromosomal Location of Human Ortholog: 2q11.2

Cellular Component: cytosol

Molecular Function:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity

Biological Process: inositol phosphate metabolic process; dephosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; signal transduction

NCBI Summary:This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008]
UniProt Code:Q96PE3
NCBI GenInfo Identifier:119622315
NCBI Gene ID:3631
NCBI Accession:EAX01910.1
UniProt Secondary Accession:Q96PE3,O15326, Q13187, Q53TD8, Q8TC02,
UniProt Related Accession:Q96PE3
Molecular Weight:109,956 Da
NCBI Full Name:inositol polyphosphate-4-phosphatase, type I, 107kDa, isoform CRA_f
NCBI Synonym Full Names:inositol polyphosphate-4-phosphatase, type I, 107kDa
NCBI Official Symbol:INPP4A  
NCBI Official Synonym Symbols:INPP4; TVAS1  
NCBI Protein Information:type I inositol 3,4-bisphosphate 4-phosphatase; type I inositol-3,4-bisphosphate 4-phosphatase; inositol polyphosphate-4-phosphatase, type I, 107kD
UniProt Protein Name:Type I inositol 3,4-bisphosphate 4-phosphatase
UniProt Synonym Protein Names:Inositol polyphosphate 4-phosphatase type I
Protein Family:Type I inositol 3,4-bisphosphate 4-phosphatase
UniProt Gene Name:INPP4A  
UniProt Entry Name:INP4A_HUMAN
Anti-INPP4A Antibody (CAB7691)Western blot analysis of extracts of various cell lines, using INPP4A antibody (CAB7691) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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