Cell Biology Antibodies 11
Anti-INHBC Antibody (CAB7559)
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- SKU:
- CAB7559
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-INHBC Antibody |
| Antibody SKU: | CAB7559 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 103-352 of human INHBC (NP_005529.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, A-549, HT-29, BT-474, Mouse pancreas, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 103-352 of human INHBC (NP_005529.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ETGL STIN QTRL DFHF SSDR TAGD REVQ QASL MFFV QLPS NTTW TLKV RVLV LGPH NTNL TLAT QYLL EVDA SGWH QLPL GPEA QAAC SQGH LTLE LVLE GQVA QSSV ILGG AAHR PFVA ARVR VGGK HQIH RRGI DCQG GSRM CCRQ EFFV DFRE IGWH DWII QPEG YAMN FCIG QCPL HIAG MPGI AASF HTAV LNLL KANT AAGT TGGG SCCV PTAR RPLS LLYY DRDS NIVK TDIP DMVV EACG CS |
| Gene ID: | 3626 |
| Uniprot: | P55103 |
| Cellular Location: | Secreted |
| Calculated MW: | 38kDa |
| Observed MW: | 38kDa |
| Synonyms: | INHBC, IHBC |
| Background: | This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. |
| UniProt Protein Function: | INHBC: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 12q13.1 Cellular Component: extracellular region; extracellular space Molecular Function:cytokine activity; growth factor activity; hormone activity; transforming growth factor beta receptor binding Biological Process: cell development; regulation of apoptosis; regulation of MAPKKK cascade |
| NCBI Summary: | This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P55103 |
| NCBI GenInfo Identifier: | 1708438 |
| NCBI Gene ID: | 3626 |
| NCBI Accession: | P55103.1 |
| UniProt Secondary Accession: | P55103,A1L3Y2, |
| UniProt Related Accession: | P55103 |
| Molecular Weight: | 38,238 Da |
| NCBI Full Name: | Inhibin beta C chain |
| NCBI Synonym Full Names: | inhibin beta C |
| NCBI Official Symbol: | INHBC |
| NCBI Official Synonym Symbols: | IHBC |
| NCBI Protein Information: | inhibin beta C chain |
| UniProt Protein Name: | Inhibin beta C chain |
| UniProt Synonym Protein Names: | Activin beta-C chain |
| Protein Family: | Inhibin |
| UniProt Gene Name: | INHBC |
| UniProt Entry Name: | INHBC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using INHBC antibody (CAB7559) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using INHBC antibody (CAB7559) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using INHBC antibody (CAB7559) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using INHBC antibody (CAB7559) at dilution of 1:100 (40x lens). |
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