Antibody Name:	Anti-INHBB Antibody
Antibody SKU:	CAB8553
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 293-407 of human INHBB (NP_002184.2).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:	Human, Mouse
Positive Samples:	U-87MG, A-549, MCF7, SW620

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 293-407 of human INHBB (NP_002184.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	GLEC DGRT NLCC RQQF FIDF RLIG WNDW IIAP TGYY GNYC EGSC PAYL AGVP GSAS SFHT AVVN QYRM RGLN PGTV NSCC IPTK LSTM SMLY FDDE YNIV KRDV PNMI VEEC GCA
Gene ID:	3625
Uniprot:	P09529
Cellular Location:	Secreted
Calculated MW:	45kDa
Observed MW:	45kDa

Synonyms:

INHBB

Background:

The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.

UniProt Protein Function:	INHBB: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.
UniProt Protein Details:	Protein type:Secreted, signal peptide; Cytokine; Secreted; Cell development/differentiation Chromosomal Location of Human Ortholog: 2cen-q13 Cellular Component: extracellular region; extracellular space; perinuclear region of cytoplasm Molecular Function:cytokine activity; growth factor activity; hormone activity; host cell surface receptor binding; protein binding; protein homodimerization activity; transforming growth factor beta receptor binding Biological Process: activin receptor signaling pathway; cell development; cell differentiation; cellular response to insulin stimulus; cellular response to starvation; defense response; fat cell differentiation; growth; negative regulation of follicle-stimulating hormone secretion; negative regulation of hepatocyte growth factor biosynthetic process; negative regulation of insulin secretion; oocyte development; ovarian follicle development; positive regulation of follicle-stimulating hormone secretion; regulation of apoptosis; regulation of MAPKKK cascade; response to mechanical stimulus
NCBI Summary:	The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq, Jul 2008]
UniProt Code:	P09529
NCBI GenInfo Identifier:	1708437
NCBI Gene ID:	3625
NCBI Accession:	P09529.2
UniProt Secondary Accession:	P09529,Q53T31, Q8N1D3,
UniProt Related Accession:	P09529
Molecular Weight:	45,122 Da
NCBI Full Name:	Inhibin beta B chain
NCBI Synonym Full Names:	inhibin beta B
NCBI Official Symbol:	INHBB
NCBI Protein Information:	inhibin beta B chain
UniProt Protein Name:	Inhibin beta B chain
UniProt Synonym Protein Names:	Activin beta-B chain
Protein Family:	Inhibin
UniProt Gene Name:	INHBB
UniProt Entry Name:	INHBB_HUMAN

	Western blot analysis of extracts of various cell lines, using INHBB antibody (CAB8553) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
	Immunohistochemistry of paraffin-embedded mouse lung using INHBB antibody (CAB8553) at dilution of 1:100 (40x lens).