Cell Cycle Antibodies 2
Anti-ING1 Antibody (CAB7904)
- SKU:
- CAB7904
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-ING1 Antibody |
| Antibody SKU: | CAB7904 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human ING1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SKOV3, HT-29, NIH/3T3, Mouse testis, Mouse brain, Mouse spleen, Mouse lung, Rat brain, Rat liver |
| Immunogen: | A synthetic peptide of human ING1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3621 |
| Uniprot: | Q9UK53 |
| Cellular Location: | Nucleus |
| Calculated MW: | 23kDa/26kDa/29kDa/31kDa/46kDa |
| Observed MW: | 47kDa |
| Synonyms: | ING1, p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a |
| Background: | This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| UniProt Protein Function: | ING1: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC); also known as squamous cell carcinoma of the head and neck. Belongs to the ING family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: 13q34 Cellular Component: cytoplasm; nucleoplasm Molecular Function:methylated histone residue binding; protein binding Disease: Squamous Cell Carcinoma, Head And Neck |
| NCBI Summary: | This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UK53 |
| NCBI GenInfo Identifier: | 212276438 |
| NCBI Gene ID: | 3621 |
| NCBI Accession: | Q9UK53.2 |
| UniProt Secondary Accession: | Q9UK53,O00532, O43658, Q53ZR3, Q5T9G8, Q5T9G9, Q5T9H0 Q5T9H1, Q9H007, Q9HD98, Q9HD99, Q9NS83, |
| UniProt Related Accession: | Q9UK53 |
| Molecular Weight: | 29,572 Da |
| NCBI Full Name: | Inhibitor of growth protein 1 |
| NCBI Synonym Full Names: | inhibitor of growth family member 1 |
| NCBI Official Symbol: | ING1 |
| NCBI Official Synonym Symbols: | p33; p47; p33ING1; p24ING1c; p33ING1b; p47ING1a |
| NCBI Protein Information: | inhibitor of growth protein 1 |
| UniProt Protein Name: | Inhibitor of growth protein 1 |
| Protein Family: | Inhibitor of growth protein |
| UniProt Gene Name: | ING1 |
| UniProt Entry Name: | ING1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ING1 antibody (CAB7904) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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