Cell Biology Antibodies 2

Anti-INADL Antibody (CAB12063)

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SKU:
CAB12063
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-INADL Antibody
Antibody SKU:CAB12063
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human INADL (NP_795352.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human INADL (NP_795352.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPEN PATD KLQV LQVL DRLK MKLQ EKGD TSQN EKLS MFYE TLKS PLFN QILT LQQS IKQL KGQL NHIP SDCS ANFD FSRK GLLV FTDG SITN GNVH RPSN
Gene ID:10207
Uniprot:Q8NI35
Cellular Location:Apical cell membrane, Cell junction, Cell membrane, Cytoplasm, Peripheral membrane protein, perinuclear region, tight junction
Calculated MW:125kDa/167kDa/170kDa/173kDa/196kDa
Observed MW:170kDa
Synonyms:PATJ, Cipp, INADL, InaD-like, hINADL
Background:This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.
UniProt Protein Function:Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950).
NCBI Summary:This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008]
UniProt Code:Q8NI35
NCBI GenInfo Identifier:116242542
NCBI Gene ID:10207
NCBI Accession:Q8NI35.3
UniProt Secondary Accession:Q8NI35,O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7 Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9,
UniProt Related Accession:Q8NI35
Molecular Weight:125,231 Da
NCBI Full Name:InaD-like protein
NCBI Synonym Full Names:PATJ, crumbs cell polarity complex component
NCBI Official Symbol:PATJ  
NCBI Official Synonym Symbols:Cipp; INADL; hINADL; InaD-like  
NCBI Protein Information:inaD-like protein
UniProt Protein Name:InaD-like protein
UniProt Synonym Protein Names:Pals1-associated tight junction protein; Protein associated to tight junctions
Protein Family:Patj
UniProt Gene Name:PATJ  
Anti-INADL Antibody (CAB12063)Western blot analysis of extracts of mouse brain, using INADL antibody (CAB12063) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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