Metabolism Antibodies 3
Anti-IMPDH2 Antibody (CAB9208)
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- SKU:
- CAB9208
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-IMPDH2 Antibody |
| Antibody SKU: | CAB9208 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human IMPDH2 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HepG2, A-549, K-562, Rat spleen |
| Immunogen: | A synthesized peptide derived from human IMPDH2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3615 |
| Uniprot: | P12268 |
| Cellular Location: | |
| Calculated MW: | 56kDa |
| Observed MW: | 56KDa |
| Synonyms: | IMPD2, IMPDH-II |
| Background: | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| NCBI Summary: | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12268 |
| NCBI GenInfo Identifier: | 124419 |
| NCBI Gene ID: | 3615 |
| NCBI Accession: | P12268.2 |
| UniProt Secondary Accession: | P12268,Q6LEF3, |
| UniProt Related Accession: | P12268 |
| Molecular Weight: | 55,805 Da |
| NCBI Full Name: | Inosine-5'-monophosphate dehydrogenase 2 |
| NCBI Synonym Full Names: | inosine monophosphate dehydrogenase 2 |
| NCBI Official Symbol: | IMPDH2 |
| NCBI Official Synonym Symbols: | IMPD2; IMPDH-II |
| NCBI Protein Information: | inosine-5'-monophosphate dehydrogenase 2 |
| UniProt Protein Name: | Inosine-5'-monophosphate dehydrogenase 2 |
| UniProt Synonym Protein Names: | IMPDH-II |
| UniProt Gene Name: | IMPDH2 |
 | Western blot - IMPDH2 Rabbit mAb (CAB9208) |
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