Metabolism Antibodies 3

Anti-IMPDH2 Antibody (CAB9208)

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SKU:
CAB9208
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-IMPDH2 Antibody
Antibody SKU:CAB9208
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human IMPDH2
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HepG2, A-549, K-562, Rat spleen
Immunogen:A synthesized peptide derived from human IMPDH2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3615
Uniprot:P12268
Cellular Location:
Calculated MW:56kDa
Observed MW:56KDa
Synonyms:IMPD2, IMPDH-II
Background:This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
UniProt Protein Function:Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
NCBI Summary:This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
UniProt Code:P12268
NCBI GenInfo Identifier:124419
NCBI Gene ID:3615
NCBI Accession:P12268.2
UniProt Secondary Accession:P12268,Q6LEF3,
UniProt Related Accession:P12268
Molecular Weight:55,805 Da
NCBI Full Name:Inosine-5'-monophosphate dehydrogenase 2
NCBI Synonym Full Names:inosine monophosphate dehydrogenase 2
NCBI Official Symbol:IMPDH2  
NCBI Official Synonym Symbols:IMPD2; IMPDH-II  
NCBI Protein Information:inosine-5'-monophosphate dehydrogenase 2
UniProt Protein Name:Inosine-5'-monophosphate dehydrogenase 2
UniProt Synonym Protein Names:IMPDH-II
UniProt Gene Name:IMPDH2  
Anti-IMPDH2 Antibody (CAB9208)Western blot - IMPDH2 Rabbit mAb (CAB9208)
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