Anti-ILF2 Antibody (CAB9530)

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SKU:
CAB9530
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NF45
Synonyms:
PRO3063
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:ILF2 Rabbit mAb
Product Code:CAB9530
Size:20uL, 50uL, 100uL
Synonyms:NF45, PRO3063
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ILF2
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HepG2, Raji, Mouse thymus, Rat testis
Immunogen:A synthesized peptide derived from human ILF2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3608
Uniprot:Q12905
Calculated MW:43kDa
Observed MW:43KDa
UniProt Protein Function:ILF2: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA.
UniProt Protein Details:

Protein type:RNA-binding; Transcription, coactivator/corepressor; Nucleolus

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; ribonucleoprotein complex; nucleus

Molecular Function:transferase activity; protein binding; DNA binding; double-stranded RNA binding; ATP binding

Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; immune response

NCBI Summary:The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]
UniProt Code:Q12905
NCBI GenInfo Identifier:62510764
NCBI Gene ID:3608
NCBI Accession:Q12905.2
UniProt Secondary Accession:Q12905,Q5SR10, Q5SR11, Q7L7R3, Q9BWD4, Q9P1N0, A6NDB0 B2R8G7,
UniProt Related Accession:Q12905
Molecular Weight:390
NCBI Full Name:Interleukin enhancer-binding factor 2
NCBI Synonym Full Names:interleukin enhancer binding factor 2
NCBI Official Symbol:ILF2  
NCBI Official Synonym Symbols:NF45; PRO3063  
NCBI Protein Information:interleukin enhancer-binding factor 2; interleukin enhancer binding factor 2, 45kD; nuclear factor of activated T-cells, 45-kDa; interleukin enhancer binding factor 2, 45kDa
UniProt Protein Name:Interleukin enhancer-binding factor 2
UniProt Synonym Protein Names:Nuclear factor of activated T-cells 45 kDa
Protein Family:Interleukin enhancer-binding factor
UniProt Gene Name:ILF2  
UniProt Entry Name:ILF2_HUMAN
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