Cell Biology Antibodies 12
Anti-IL4I1 Antibody (CAB8378)
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- SKU:
- CAB8378
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-IL4I1 Antibody |
| Antibody SKU: | CAB8378 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-220 of human IL4I1 (NP_690863.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, THP-1, SKOV3, U-87MG, LO2, Mouse testis, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-220 of human IL4I1 (NP_690863.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QDWK AERS QDPF EKCM QDPD YEQL LKVV TWGL NRTL KPQR VIVV GAGV AGLV AAKV LSDA GHKV TILE ADNR IGGR IFTY RDQN TGWI GELG AMRM PSSH RILH KLCQ GLGL NLTK FTQY DKNT WTEV HEVK LRNY VVEK VPEK LGYA LRPQ EKGH SPED IYQM ALNQ ALKD LKAL GCRK AMKK FERH TLLE YLLG EGN |
| Gene ID: | 259307 |
| Uniprot: | Q96RQ9 |
| Cellular Location: | Lysosome |
| Calculated MW: | 62kDa/65kDa |
| Observed MW: | 70kDa |
| Synonyms: | IL4I1, FIG1, LAAO, LAO |
| Background: | This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing the first two exons of the upstream gene is found in other cell types. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | IL4I1: Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation. Belongs to the flavin monoamine oxidase family. FIG1 subfamily. 2 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - cysteine and methionine; Secreted; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - phenylalanine; Secreted, signal peptide; Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 1.4.3.2; Oxidoreductase Chromosomal Location of Human Ortholog: 19q13.3-q13.4 Cellular Component: extracellular region Molecular Function:L-amino-acid oxidase activity Biological Process: L-phenylalanine catabolic process |
| NCBI Summary: | This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing the first two exons of the upstream gene is found in other cell types. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q96RQ9 |
| NCBI GenInfo Identifier: | 20138284 |
| NCBI Gene ID: | 259307 |
| NCBI Accession: | Q96RQ9.1 |
| UniProt Secondary Accession: | Q96RQ9,Q1WMJ3, Q4GZN1, Q4GZN2, Q6P2Q3, Q8TEM5, Q96RQ8 |
| UniProt Related Accession: | Q96RQ9 |
| Molecular Weight: | 65,328 Da |
| NCBI Full Name: | L-amino-acid oxidase |
| NCBI Synonym Full Names: | interleukin 4 induced 1 |
| NCBI Official Symbol: | IL4I1 |
| NCBI Official Synonym Symbols: | LAO; FIG1; LAAO |
| NCBI Protein Information: | L-amino-acid oxidase |
| UniProt Protein Name: | L-amino-acid oxidase |
| UniProt Synonym Protein Names: | Interleukin-4-induced protein 1; IL4-induced protein 1; Protein Fig-1; hFIG1 |
| UniProt Gene Name: | IL4I1 |
| UniProt Entry Name: | OXLA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL4I1 antibody (CAB8378) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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