Immunology Antibodies 3

Anti-IL36RN Antibody (CAB8205)

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SKU:
CAB8205
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:IL36RN Rabbit Polyclonal Antibody
Antibody SKU:CAB8205
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-155 of human IL36RN (NP_036407.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse spleen, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-155 of human IL36RN (NP_036407.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVLS GALC FRMK DSAL KVLY LHNN QLLA GGLH AGKV IKGE EISV VPNR WLDA SLSP VILG VQGG SQCL SCGV GQEP TLTL EPVN IMEL YLGA KESK SFTF YRRD MGLT SSFE SAAY PGWF LCTV PEAD QPVR LTQL PENG GWNA PITD FYFQ QCD
Gene ID:26525
Uniprot:Q9UBH0
Cellular Location:Secreted
Calculated MW:16kDa
Observed MW:17kDa
Synonyms:IL36RN, FIL1, FIL1(DELTA), FIL1D, IL-36Ra, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, PSORS14
Background:The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported.
UniProt Protein Function:IL1F5: Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL- 1R1), that is present in epithelial barriers and takes part in local inflammatory response. Defects in IL36RN are the cause of psoriasis generalized pustular (PSORP). PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein. Belongs to the IL-1 family.
UniProt Protein Details:

Protein type:Cytokine

Chromosomal Location of Human Ortholog: 2q14

Cellular Component: extracellular space

Molecular Function:cytokine activity; interleukin-1 receptor binding; protein binding

Biological Process: antifungal humoral response; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of interleukin-17 production

Disease: Psoriasis 14, Pustular

NCBI Summary:The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UBH0
NCBI GenInfo Identifier:25008600
NCBI Gene ID:26525
NCBI Accession:Q9UBH0.1
UniProt Secondary Accession:Q9UBH0,Q56AT9, Q7RTZ6, A8K2I4,
UniProt Related Accession:Q9UBH0
Molecular Weight:16,962 Da
NCBI Full Name:Interleukin-36 receptor antagonist protein
NCBI Synonym Full Names:interleukin 36 receptor antagonist
NCBI Official Symbol:IL36RN  
NCBI Official Synonym Symbols:FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1; IL1RP3; IL36RA; IL-36Ra; PSORS14; FIL1(DELTA)  
NCBI Protein Information:interleukin-36 receptor antagonist protein
UniProt Protein Name:Interleukin-36 receptor antagonist protein
UniProt Synonym Protein Names:FIL1 delta; IL-1-related protein 3; IL-1RP3; Interleukin-1 HY1; IL-1HY1; Interleukin-1 delta; IL-1 delta; Interleukin-1 family member 5; IL-1F5; Interleukin-1 receptor antagonist homolog 1; IL-1ra homolog 1; Interleukin-1-like protein 1; IL-1L1
Protein Family:Interleukin-36 receptor antagonist protein
UniProt Gene Name:IL36RN  
UniProt Entry Name:I36RA_HUMAN
Anti-IL36RN Polyclonal Antibody (CAB8205)Western blot analysis of extracts of various cell lines, using IL36RN antibody (CAB8205) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.
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