Immunology Antibodies 3

Anti-IL36A Antibody (CAB8207)

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SKU:
CAB8207
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:IL36A Rabbit Polyclonal Antibody
Antibody SKU:CAB8207
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-158 of human IL36A (NP_055255.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, BT-474, SW480, A-431, HeLa, Mouse skin, Mouse heart, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-158 of human IL36A (NP_055255.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEKA LKID TPQQ GSIQ DINH RVWV LQDQ TLIA VPRK DRMS PVTI ALIS CRHV ETLE KDRG NPIY LGLN GLNL CLMC AKVG DQPT LQLK EKDI MDLY NQPE PVKS FLFY HSQS GRNS TFES VAFP GWFI AVSS EGGC PLIL TQEL GKAN TTDF GLTM LF
Gene ID:27179
Uniprot:Q9UHA7
Cellular Location:Secreted
Calculated MW:17kDa
Observed MW:23kDa
Synonyms:IL36A, FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6
Background:The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients.
UniProt Protein Function:IL1F6: Belongs to the IL-1 family.
UniProt Protein Details:

Protein type:Cytokine

Chromosomal Location of Human Ortholog: 2q12-q14.1

Cellular Component: extracellular region; extracellular space

Molecular Function:cytokine activity; interleukin-1 receptor binding

Biological Process: cytokine and chemokine mediated signaling pathway

NCBI Summary:The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]
UniProt Code:Q9UHA7
NCBI GenInfo Identifier:25008601
NCBI Gene ID:27179
NCBI Accession:Q9UHA7.1
UniProt Secondary Accession:Q9UHA7,Q53SR7, Q5BLR4, Q7RTZ8, B2RAD9,
UniProt Related Accession:Q9UHA7
Molecular Weight:17,684 Da
NCBI Full Name:Interleukin-36 alpha
NCBI Synonym Full Names:interleukin 36, alpha
NCBI Official Symbol:IL36A  
NCBI Official Synonym Symbols:FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON)  
NCBI Protein Information:interleukin-36 alpha
UniProt Protein Name:Interleukin-36 alpha
UniProt Synonym Protein Names:FIL1 epsilon; Interleukin-1 epsilon; IL-1 epsilon; Interleukin-1 family member 6; IL-1F6
Protein Family:Interleukin
UniProt Gene Name:IL36A  
UniProt Entry Name:IL36A_HUMAN
Anti-IL36A Polyclonal Antibody (CAB8207)Western blot analysis of extracts of various cell lines, using IL36A antibody (CAB8207) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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