Description
| Product Name: | IL15RA Rabbit pAb |
| Product Code: | CAB2983 |
| Size: | 100uL |
| Synonyms: | IL15RA, CD215 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-205 of human IL15RA (NP_002180.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:1000 |
| Reactivity: | Human |
| Positive Samples: | THP-1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-205 of human IL15RA (NP_002180.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3601 |
| Uniprot: | Q13261 |
| Cellular Location: | Cytoplasmic vesicle membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane, Membrane, Nucleus membrane, Secreted, Single-pass type I membrane protein, Single-pass type I membrane protein, extracellular space |
| Calculated MW: | 15-28kDa |
| Observed MW: | 60KDa |
| UniProt Protein Function: | IL15RA: High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 and SYK. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 10p15.1 Cellular Component: plasma membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; signal transducer activity Biological Process: cell proliferation; signal transduction |
| NCBI Summary: | This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010] |
| UniProt Code: | Q13261 |
| NCBI GenInfo Identifier: | 59799763 |
| NCBI Gene ID: | 3601 |
| NCBI Accession: | Q13261.1 |
| UniProt Secondary Accession: | Q13261,Q3B769, Q5JVA1, Q5JVA2, Q5JVA4, Q6B0J2, Q7LDR4 Q7Z609, B4E2C2, |
| UniProt Related Accession: | Q13261 |
| Molecular Weight: | 24,388 Da |
| NCBI Full Name: | Interleukin-15 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 15 receptor subunit alpha |
| NCBI Official Symbol: | IL15RA |
| NCBI Official Synonym Symbols: | CD215 |
| NCBI Protein Information: | interleukin-15 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-15 receptor subunit alpha |
| UniProt Synonym Protein Names: | CD_antigen: CD215 |
| Protein Family: | Interleukin-15 receptor |
| UniProt Gene Name: | IL15RA |
| UniProt Entry Name: | I15RA_HUMAN |
