Anti-IL15RA Antibody (CAB2983)

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SKU:
CAB2983
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
IL15RA
Synonyms:
CD215
Research Area:
Cell Biology

Description

Product Name:IL15RA Rabbit pAb
Product Code:CAB2983
Size:100uL
Synonyms:IL15RA, CD215
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 31-205 of human IL15RA (NP_002180.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:1000
Reactivity:Human
Positive Samples:THP-1
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 31-205 of human IL15RA (NP_002180.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3601
Uniprot:Q13261
Cellular Location:Cytoplasmic vesicle membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane, Membrane, Nucleus membrane, Secreted, Single-pass type I membrane protein, Single-pass type I membrane protein, extracellular space
Calculated MW:15-28kDa
Observed MW:60KDa
UniProt Protein Function:IL15RA: High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 and SYK. 8 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10p15.1

Cellular Component: plasma membrane

Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; signal transducer activity

Biological Process: cell proliferation; signal transduction

NCBI Summary:This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]
UniProt Code:Q13261
NCBI GenInfo Identifier:59799763
NCBI Gene ID:3601
NCBI Accession:Q13261.1
UniProt Secondary Accession:Q13261,Q3B769, Q5JVA1, Q5JVA2, Q5JVA4, Q6B0J2, Q7LDR4 Q7Z609, B4E2C2,
UniProt Related Accession:Q13261
Molecular Weight:24,388 Da
NCBI Full Name:Interleukin-15 receptor subunit alpha
NCBI Synonym Full Names:interleukin 15 receptor subunit alpha
NCBI Official Symbol:IL15RA  
NCBI Official Synonym Symbols:CD215  
NCBI Protein Information:interleukin-15 receptor subunit alpha
UniProt Protein Name:Interleukin-15 receptor subunit alpha
UniProt Synonym Protein Names:CD_antigen: CD215
Protein Family:Interleukin-15 receptor
UniProt Gene Name:IL15RA  
UniProt Entry Name:I15RA_HUMAN
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