Cell Biology Antibodies 10
Anti-IL-9R Antibody (CAB6630)
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- SKU:
- CAB6630
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL9R Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB6630 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human IL9R (XP_011529456.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NIH/3T3, Mouse thymus |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human IL9R (XP_011529456.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PELG QGSS PWLL FTSN QAPG GTHK CILR GSEC TVVL PPEA VLVP SDNF TITF HHCM SGRE QVSL VDPE YLPR RHVK LDPP SDLQ SNIS SGHC ILTW SISP A |
| Gene ID: | 3581 |
| Uniprot: | Q01113 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 37kDa/54kDa/57kDa |
| Observed MW: | 57kDa |
| Synonyms: | IL9R, CD129, IL-9R |
| Background: | The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | IL9R: This is a receptor for interleukin-9. Belongs to the type I cytokine receptor family. Type 4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: Xq28 and Yq12 Cellular Component: extracellular space; integral to plasma membrane Molecular Function:interleukin-9 binding; interleukin-9 receptor activity Biological Process: cell proliferation; signal transduction; positive regulation of cell growth |
| NCBI Summary: | The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q01113 |
| NCBI GenInfo Identifier: | 116242526 |
| NCBI Gene ID: | 3581 |
| NCBI Accession: | Q01113.3 |
| UniProt Secondary Accession: | Q01113,Q14634, Q8WWU1, Q96TF0, B9ZVT0, |
| UniProt Related Accession: | Q01113 |
| Molecular Weight: | 521 |
| NCBI Full Name: | Interleukin-9 receptor |
| NCBI Synonym Full Names: | interleukin 9 receptor |
| NCBI Official Symbol: | IL9R |
| NCBI Official Synonym Symbols: | CD129; IL-9R |
| NCBI Protein Information: | interleukin-9 receptor; IL-9 receptor |
| UniProt Protein Name: | Interleukin-9 receptor |
| UniProt Synonym Protein Names: | CD_antigen: CD129 |
| Protein Family: | Interleukin-9 receptor |
| UniProt Gene Name: | IL9R |
| UniProt Entry Name: | IL9R_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL9R antibody (CAB6630) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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