Cell Biology Antibodies 6
Anti-IL-6R Antibody (CAB1570)
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- SKU:
- CAB1570
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL6R Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB1570 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human IL6R (NP_000556.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | SW480 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human IL6R (NP_000556.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LAPR RCPA QEVA RGVL TSLP GDSV TLTC PGVE PEDN ATVH WVLR KPAA GSHP SRWA GMGR RLLL RSVQ LHDS GNYS CYRA GRPA GTVH LLVD VPPE EPQL SCFR KSPL SNVV CEWG PRST PSLT TKAV LLVR KFQN SPAE DFQE PCQY SQES QKFS CQLA VPEG DSSF YIVS MCVA SSVG SKFS KTQT FQGC GILQ PDPP ANIT VTAV ARNP RWLS VTWQ DPHS WNSS FYRL RFEL RYRA ERSK TFTT WMVK DLQH HCVI HDAW SGLR HVVQ LRAQ EEFG QGEW SEWS PEAM GTPW TESR S |
| Gene ID: | 3570 |
| Uniprot: | P08887 |
| Cellular Location: | Basolateral cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 40kDa/51kDa |
| Observed MW: | 80kDa |
| Synonyms: | IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80 |
| Background: | This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9. |
| UniProt Protein Function: | Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. |
| NCBI Summary: | This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011] |
| UniProt Code: | P08887 |
| NCBI GenInfo Identifier: | 124343 |
| NCBI Gene ID: | 3570 |
| NCBI Accession: | P08887.1 |
| UniProt Secondary Accession: | P08887,Q16202, Q53EQ7, Q5FWG2, Q5VZ23, A8KAE8, B2R6V4 |
| UniProt Related Accession: | P08887 |
| Molecular Weight: | 40,237 Da |
| NCBI Full Name: | Interleukin-6 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 6 receptor |
| NCBI Official Symbol: | IL6R |
| NCBI Official Synonym Symbols: | IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1 |
| NCBI Protein Information: | interleukin-6 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-6 receptor subunit alpha |
| UniProt Synonym Protein Names: | IL-6R 1; Membrane glycoprotein 80; gp80; CD_antigen: CD126 |
| Protein Family: | Interleukin-6 receptor |
| UniProt Gene Name: | IL6R |
 | Western blot analysis of extracts of SW480 cells, using IL6R antibody (CAB1570) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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