Immunology Antibodies 2
Anti-IL-6 Antibody (CAB2447)
- SKU:
- CAB2447
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | IL6 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB2447 |
| Antibody Size: | 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human IL6 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NCI-H460, 293T, K-562, Rat lung, Rat kidney |
| Immunogen: | A synthetic peptide of human IL6 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3569 |
| Uniprot: | P05231 |
| Cellular Location: | Secreted |
| Calculated MW: | 23kDa |
| Observed MW: | 26kDa |
| Synonyms: | IL6, BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6 |
| Background: | This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. |
| UniProt Code: | P05231 |
| NCBI GenInfo Identifier: | 124347 |
| NCBI Gene ID: | 3569 |
| NCBI Accession: | P05231.1 |
| UniProt Secondary Accession: | P05231,Q9UCU2, Q9UCU3, Q9UCU4, |
| UniProt Related Accession: | P05231 |
| Molecular Weight: | 212 |
| NCBI Full Name: | Interleukin-6 |
| NCBI Synonym Full Names: | interleukin 6 |
| NCBI Official Symbol: | IL6 |
| NCBI Official Synonym Symbols: | HGF; HSF; BSF2; IL-6; IFNB2 |
| NCBI Protein Information: | interleukin-6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; interferon, beta 2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor |
| UniProt Protein Name: | Interleukin-6 |
| UniProt Synonym Protein Names: | B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL6 |
| UniProt Entry Name: | IL6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL6 antibody (CAB2447) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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