Cell Biology Antibodies 9
Anti-IL-3RA Antibody (CAB3926)
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- SKU:
- CAB3926
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL3RA Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB3926 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IL3RA (NP_002174.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IL3RA (NP_002174.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVLL WLTL LLIA LPCL LQTK EDPN PPIT NLRM KAKA QQLT WDLN RNVT DIEC VKDA DYSM PAVN NSYC QFGA ISLC EVTN YTVR VANP PFST WILF PENS |
| Gene ID: | 3563 |
| Uniprot: | P26951 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 34kDa/43kDa |
| Observed MW: | 70kDa |
| Synonyms: | IL3RA, CD123, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra |
| Background: | The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. |
| UniProt Protein Function: | IL3RA: This is a receptor for interleukin-3. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xp22.3 or Yp11.3 Cellular Component: plasma membrane; integral to membrane Molecular Function:interleukin-3 receptor activity |
| NCBI Summary: | The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012] |
| UniProt Code: | P26951 |
| NCBI GenInfo Identifier: | 417184 |
| NCBI Gene ID: | 3563 |
| NCBI Accession: | P26951.1 |
| UniProt Related Accession: | P26951 |
| Molecular Weight: | |
| NCBI Full Name: | Interleukin-3 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 3 receptor subunit alpha |
| NCBI Official Symbol: | IL3RA |
| NCBI Official Synonym Symbols: | IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra |
| NCBI Protein Information: | interleukin-3 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-3 receptor subunit alpha |
| UniProt Synonym Protein Names: | CD_antigen: CD123 |
| Protein Family: | Interleukin-3 receptor |
| UniProt Gene Name: | IL3RA |
| UniProt Entry Name: | IL3RA_HUMAN |
 | Western blot analysis of extracts of A-549 cells, using IL3RA antibody (CAB3926) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat lung using IL3RA antibody (CAB3926) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using IL3RA antibody (CAB3926) at dilution of 1:100 (40x lens). |
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