| UniProt Protein Function: | IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine Chromosomal Location of Human Ortholog: 9p24.1 Cellular Component: extracellular space; transport vesicle; chromosome; nucleus Molecular Function:protein binding; cytokine activity Biological Process: T-helper 2 type immune response; negative regulation of T-helper 1 type immune response; positive regulation of T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of macrophage activation; positive regulation of inflammatory response |
| NCBI Summary: | IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011] |
| UniProt Code: | O95760 |
| NCBI GenInfo Identifier: | 68565855 |
| NCBI Gene ID: | 90865 |
| NCBI Accession: | O95760.1 |
| UniProt Secondary Accession: | O95760,Q2YEJ5, B2R8L1, B4DJ35, B4E1Q9, D3DRI5, E7EAX4 |
| UniProt Related Accession: | O95760 |
| Molecular Weight: | 16,250 Da |
| NCBI Full Name: | Interleukin-33 |
| NCBI Synonym Full Names: | interleukin 33 |
| NCBI Official Symbol: | IL33 |
| NCBI Official Synonym Symbols: | DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26 |
| NCBI Protein Information: | interleukin-33; IL-33; IL-1F11; DVS27-related protein; interleukin-1 family member 11; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules |
| UniProt Protein Name: | Interleukin-33 |
| UniProt Synonym Protein Names: | Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL33 |
| UniProt Entry Name: | IL33_HUMAN |
