Immunology Antibodies 2
Anti-IL-31RA Antibody (CAB6141)
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- SKU:
- CAB6141
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | IL31RA Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB6141 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human IL31RA (NP_001229568.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse liver, Mouse heart, Mouse brain, Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human IL31RA (NP_001229568.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTYW RLEN IAKT EPPK IFRV KPVL GIKR MIQI EWIK PELA PVSS DLKY TLRF RTVN STSW MEVN FAKN RKDK NQTY NLTG LQPF TEYV IALR CAVK ESKF WSDW SQEK MGMT EEEA PCGL ELWR VLKP AEAD GRRP VRLL WKKA RGAP VLEK TLGY NIWY YPES NTNL TETM NTTN QQLE LHLG GESF WVSM ISYN SLGK SPVA TLRI PAIQ EKSF QCIE VMQA CVAE DQLV VKWQ SSAL DVNT WMIE WFPD VDSE PTTL SWES VSQA TNWT IQQD KLKP FWCY NISV YPML HDKV GEPY |
| Gene ID: | 133396 |
| Uniprot: | Q8NI17 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 41kDa/58-86kDa |
| Observed MW: | 83kDa |
| Synonyms: | IL31RA, CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384, hGLM-R |
| Background: | The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. |
| UniProt Protein Function: | IL31RA: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Defects in IL31RA are the cause of amyloidosis primary localized cutaneous type 2 (PLCA2). PLCA2 is primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Belongs to the type I cytokine receptor family. Type 2 subfamily. 12 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q11.2 Cellular Component: plasma membrane; integral to membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; cytokine binding; transcription coactivator activity; protein kinase binding Biological Process: macrophage differentiation; monocyte differentiation; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; MAPKKK cascade; defense response; JAK-STAT cascade; positive regulation of tyrosine phosphorylation of Stat3 protein; homeostatic process; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of cell proliferation; negative regulation of macrophage activation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis Disease: Amyloidosis, Primary Localized Cutaneous, 2 |
| NCBI Summary: | The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011] |
| UniProt Code: | Q8NI17 |
| NCBI GenInfo Identifier: | 74730327 |
| NCBI Gene ID: | 133396 |
| NCBI Accession: | Q8NI17.1 |
| UniProt Secondary Accession: | Q8NI17,Q2TBA1, Q6EBC3, Q6EBC4, Q6EBC5, Q6EBC6, Q6UWL8 Q8WYJ0, A6NIF8, |
| UniProt Related Accession: | Q8NI17 |
| Molecular Weight: | 732 |
| NCBI Full Name: | Interleukin-31 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 31 receptor A |
| NCBI Official Symbol: | IL31RA |
| NCBI Official Synonym Symbols: | CRL; GPL; CRL3; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384 |
| NCBI Protein Information: | interleukin-31 receptor subunit alpha; zcytoR17; IL-31R subunit alpha; cytokine receptor-like 3; class I cytokine receptor; IL-31 receptor subunit alpha; gp130-like monocyte receptor; soluble type I cytokine receptor CRL3 |
| UniProt Protein Name: | Interleukin-31 receptor subunit alpha |
| UniProt Synonym Protein Names: | Cytokine receptor-like 3; GLM-R; hGLM-R; Gp130-like monocyte receptor; Gp130-like receptor; ZcytoR17 |
| Protein Family: | Interleukin-31 receptor |
| UniProt Gene Name: | IL31RA |
| UniProt Entry Name: | IL31R_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL31RA antibody (CAB6141) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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