Immunology Antibodies 1
Anti-IL-31 Antibody (CAB14982)
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- SKU:
- CAB14982
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | IL31 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB14982 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-164 of human IL31 (NP_001014358.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, HT-29, Mouse spleen, Mouse kidney, Mouse thymus, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-164 of human IL31 (NP_001014358.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SHTL PVRL LRPS DDVQ KIVE ELQS LSKM LLKD VEEE KGVL VSQN YTLP CLSP DAQP PNNI HSPA IRAY LKTI RQLD NKSV IDEI IEHL DKLI FQDA PETN ISVP TDTH ECKR FILT ISQQ FSEC MDLA LKSL TSGA QQAT T |
| Gene ID: | 386653 |
| Uniprot: | Q6EBC2 |
| Cellular Location: | Secreted |
| Calculated MW: | 18kDa |
| Observed MW: | 18kDa |
| Synonyms: | IL31, IL-31 |
| Background: |
| UniProt Protein Function: | IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity. |
| UniProt Protein Details: | Protein type:Secreted; Cytokine; Secreted, signal peptide Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: extracellular space Molecular Function:cytokine activity Biological Process: immune system process |
| NCBI Summary: | IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q6EBC2 |
| NCBI GenInfo Identifier: | 62122911 |
| NCBI Gene ID: | 386653 |
| NCBI Accession: | NP_001014358.1 |
| UniProt Secondary Accession: | Q6EBC2,A2RUQ1, |
| UniProt Related Accession: | Q6EBC2 |
| Molecular Weight: | 18,205 Da |
| NCBI Full Name: | interleukin-31 |
| NCBI Synonym Full Names: | interleukin 31 |
| NCBI Official Symbol: | IL31 |
| NCBI Official Synonym Symbols: | IL-31 |
| NCBI Protein Information: | interleukin-31 |
| UniProt Protein Name: | Interleukin-31 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL31 |
| UniProt Entry Name: | IL31_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL31 antibody (CAB14982) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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