Immunology Antibodies 2

Anti-IL-2RG Antibody (CAB1829)

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SKU:
CAB1829
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:IL2RG Rabbit Polyclonal Antibody
Antibody SKU:CAB1829
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 23-260 of human IL2RG (NP_000197.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:K-562, Mouse thymus, Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 23-260 of human IL2RG (NP_000197.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LNTT ILTP NGNE DTTA DFFL TTMP TDSL SVST LPLP EVQC FVFN VEYM NCTW NSSS EPQP TNLT LHYW YKNS DNDK VQKC SHYL FSEE ITSG CQLQ KKEI HLYQ TFVV QLQD PREP RRQA TQML KLQN LVIP WAPE NLTL HKLS ESQL ELNW NNRF LNHC LEHL VQYR TDWD HSWT EQSV DYRH KFSL PSVD GQKR YTFR VRSR FNPL CGSA QHWS EWSH PIHW GSNT SKEN PFLF AL
Gene ID:3561
Uniprot:P31785
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:20kDa/42kDa
Observed MW:40kDa
Synonyms:IL2RG, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1
Background:The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
UniProt Protein Function:IL2RG: Common subunit for the receptors for a variety of interleukins. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell- negative (XSCID); also known as agammaglobulinemia Swiss type. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell- mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID). XCID is a less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID. Belongs to the type I cytokine receptor family. Type 5 subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: Xq13.1

Cellular Component: membrane; integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function:protein binding; interleukin-4 receptor activity; interleukin-2 receptor activity; interleukin-7 binding; interleukin-7 receptor activity; interleukin-2 binding

Biological Process: viral reproduction; immune response; signal transduction

Disease: Combined Immunodeficiency, X-linked; Severe Combined Immunodeficiency, X-linked

NCBI Summary:The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
UniProt Code:P31785
NCBI GenInfo Identifier:400048
NCBI Gene ID:3561
NCBI Accession:P31785.1
UniProt Secondary Accession:P31785,Q5FC12,
UniProt Related Accession:P31785
Molecular Weight:369
NCBI Full Name:Cytokine receptor common subunit gamma
NCBI Synonym Full Names:interleukin 2 receptor, gamma
NCBI Official Symbol:IL2RG  
NCBI Official Synonym Symbols:P64; CIDX; IMD4; CD132; SCIDX; IL-2RG; SCIDX1  
NCBI Protein Information:cytokine receptor common subunit gamma; gammaC; CD132 antigen; IL-2R subunit gamma; IL-2 receptor subunit gamma; common cytokine receptor gamma chain
UniProt Protein Name:Cytokine receptor common subunit gamma
UniProt Synonym Protein Names:Interleukin-2 receptor subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; gammaC; p64; CD_antigen: CD132
Protein Family:Cytokine receptor
UniProt Gene Name:IL2RG  
UniProt Entry Name:IL2RG_HUMAN
Anti-IL-2RG Antibody (CAB1829)Western blot analysis of extracts of various cell lines, using IL2RG antibody (CAB1829) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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