Immunology Antibodies 2
Anti-IL-2RG Antibody (CAB1829)
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- SKU:
- CAB1829
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | IL2RG Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB1829 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-260 of human IL2RG (NP_000197.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | K-562, Mouse thymus, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-260 of human IL2RG (NP_000197.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LNTT ILTP NGNE DTTA DFFL TTMP TDSL SVST LPLP EVQC FVFN VEYM NCTW NSSS EPQP TNLT LHYW YKNS DNDK VQKC SHYL FSEE ITSG CQLQ KKEI HLYQ TFVV QLQD PREP RRQA TQML KLQN LVIP WAPE NLTL HKLS ESQL ELNW NNRF LNHC LEHL VQYR TDWD HSWT EQSV DYRH KFSL PSVD GQKR YTFR VRSR FNPL CGSA QHWS EWSH PIHW GSNT SKEN PFLF AL |
| Gene ID: | 3561 |
| Uniprot: | P31785 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 20kDa/42kDa |
| Observed MW: | 40kDa |
| Synonyms: | IL2RG, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1 |
| Background: | The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. |
| UniProt Protein Function: | IL2RG: Common subunit for the receptors for a variety of interleukins. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell- negative (XSCID); also known as agammaglobulinemia Swiss type. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell- mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID). XCID is a less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID. Belongs to the type I cytokine receptor family. Type 5 subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: Xq13.1 Cellular Component: membrane; integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:protein binding; interleukin-4 receptor activity; interleukin-2 receptor activity; interleukin-7 binding; interleukin-7 receptor activity; interleukin-2 binding Biological Process: viral reproduction; immune response; signal transduction Disease: Combined Immunodeficiency, X-linked; Severe Combined Immunodeficiency, X-linked |
| NCBI Summary: | The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010] |
| UniProt Code: | P31785 |
| NCBI GenInfo Identifier: | 400048 |
| NCBI Gene ID: | 3561 |
| NCBI Accession: | P31785.1 |
| UniProt Secondary Accession: | P31785,Q5FC12, |
| UniProt Related Accession: | P31785 |
| Molecular Weight: | 369 |
| NCBI Full Name: | Cytokine receptor common subunit gamma |
| NCBI Synonym Full Names: | interleukin 2 receptor, gamma |
| NCBI Official Symbol: | IL2RG |
| NCBI Official Synonym Symbols: | P64; CIDX; IMD4; CD132; SCIDX; IL-2RG; SCIDX1 |
| NCBI Protein Information: | cytokine receptor common subunit gamma; gammaC; CD132 antigen; IL-2R subunit gamma; IL-2 receptor subunit gamma; common cytokine receptor gamma chain |
| UniProt Protein Name: | Cytokine receptor common subunit gamma |
| UniProt Synonym Protein Names: | Interleukin-2 receptor subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; gammaC; p64; CD_antigen: CD132 |
| Protein Family: | Cytokine receptor |
| UniProt Gene Name: | IL2RG |
| UniProt Entry Name: | IL2RG_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL2RG antibody (CAB1829) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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