Immunology Antibodies 2

Anti-IL-2RB Antibody (CAB6207)

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SKU:
CAB6207
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:IL2RB Rabbit Polyclonal Antibody
Antibody SKU:CAB6207
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-240 of human IL2RB (NP_000869.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, Raji, RAW264.7
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-240 of human IL2RB (NP_000869.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AVNG TSQF TCFY NSRA NISC VWSQ DGAL QDTS CQVH AWPD RRRW NQTC ELLP VSQA SWAC NLIL GAPD SQKL TTVD IVTL RVLC REGV RWRV MAIQ DFKP FENL RLMA PISL QVVH VETH RCNI SWEI SQAS HYFE RHLE FEAR TLSP GHTW EEAP LLTL KQKQ EWIC LETL TPDT QYEF QVRV KPLQ GEFT TWSP WSQP LAFR TKPA ALGK DT
Gene ID:3560
Uniprot:P14784
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:61kDa
Observed MW:75KDa
Synonyms:IL2RB, CD122, IL15RB, P70-75
Background:The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.
UniProt Protein Function:IL2RB: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I. Belongs to the type I cytokine receptor family. Type 4 subfamily.
UniProt Protein Details:

Protein type:Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: external side of plasma membrane; integral to plasma membrane; intracellular; membrane; plasma membrane

Molecular Function:interleukin-2 binding; interleukin-2 receptor activity; protein binding

Biological Process: activation of MAPKK activity; axon guidance; cytokine and chemokine mediated signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; natural killer cell activation; negative regulation of apoptosis; nerve growth factor receptor signaling pathway; protein complex assembly; Ras protein signal transduction; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway; viral reproduction

NCBI Summary:The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]
UniProt Code:P14784
NCBI GenInfo Identifier:124321
NCBI Gene ID:3560
NCBI Accession:P14784.1
UniProt Secondary Accession:P14784,B2R765,
UniProt Related Accession:P14784
Molecular Weight:
NCBI Full Name:Interleukin-2 receptor subunit beta
NCBI Synonym Full Names:interleukin 2 receptor subunit beta
NCBI Official Symbol:IL2RB  
NCBI Official Synonym Symbols:CD122; IL15RB; P70-75  
NCBI Protein Information:interleukin-2 receptor subunit beta
UniProt Protein Name:Interleukin-2 receptor subunit beta
UniProt Synonym Protein Names:High affinity IL-2 receptor subunit beta; p70-75; p75; CD_antigen: CD122
Protein Family:Interleukin-2 receptor
UniProt Gene Name:IL2RB  
UniProt Entry Name:IL2RB_HUMAN
Anti-IL-2RB Antibody (CAB6207)Western blot analysis of extracts of various cell lines, using IL2RB antibody (CAB6207) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-IL-2RB Antibody (CAB6207)Western blot analysis of extracts of RAW264.7 cells, using IL2RB antibody (CAB6207) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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