Name: Anti-IL-23R Antibody (CAB1613)
Brand: Immunology Antibodies 2
SKU: CAB1613
Availability: OutOfStock

Antibody Name:	IL23R Rabbit Polyclonal Antibody
Antibody SKU:	CAB1613
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 405-629 of human IL23R (NP_653302.2).

Application:	WB IHC IF
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 405-629 of human IL23R (NP_653302.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	NSNV VKML QENS ELMN NNSS EQVL YVDP MITE IKEI FIPE HKPT DYKK ENTG PLET RDYP QNSL FDNT TVVY IPDL NTGY KPQI SNFL PEGS HLSN NNEI TSLT LKPP VDSL DSGN NPRL QKHP NFAF SVSS VNSL SNTI FLGE LSLI LNQG ECSS PDIQ NSVE EETT MLLE NDSP SETI PEQT LLPD EFVS CLGI VNEE LPSI NTYF PQNI LESH FNRI SLLE K
Gene ID:	149233
Uniprot:	Q5VWK5
Cellular Location:	Cell membrane, Single-pass type I membrane protein
Calculated MW:	20kDa/25kDa/30kDa/40kDa/42kDa/71kDa
Observed MW:	68kDa

Synonyms:	IL23R
Background:	The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.

UniProt Protein Function:	IL23R: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Genetic variations in IL23R are a cause of susceptibility to psoriasis type 7 (PSORS7). Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Belongs to the type I cytokine receptor family. Type 2 subfamily. 7 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: plasma membrane; receptor complex Molecular Function:interleukin-12 receptor binding; interleukin-23 binding; interleukin-23 receptor activity; protein binding Biological Process: defense response to Gram-negative bacterium; negative regulation of interleukin-10 production; positive regulation of activated T cell proliferation; positive regulation of defense response to virus by host; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; positive regulation of interleukin-17 production; positive regulation of memory T cell differentiation; positive regulation of natural killer cell proliferation; positive regulation of NK T cell activation; positive regulation of osteoclast differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of T-helper 1 type immune response; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of tyrosine phosphorylation of Stat4 protein; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of tyrosine phosphorylation of Stat1 protein; response to lipopolysaccharide Disease: Inflammatory Bowel Disease 17; Psoriasis 7, Susceptibility To
NCBI Summary:	The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
UniProt Code:	Q5VWK5
NCBI GenInfo Identifier:	311033431
NCBI Gene ID:	149233
NCBI Accession:	Q5VWK5.3
UniProt Secondary Accession:	Q5VWK5,Q4VGP1, Q4VGP2, Q4VGP3, Q4VGP4, Q4VGP5, Q4VGP6 Q5VWK7, Q8IW84, Q8NFQ9, Q96AS1, C9JGX4,
UniProt Related Accession:	Q5VWK5
Molecular Weight:	25,551 Da
NCBI Full Name:	Interleukin-23 receptor
NCBI Synonym Full Names:	interleukin 23 receptor
NCBI Official Symbol:	IL23R
NCBI Protein Information:	interleukin-23 receptor
UniProt Protein Name:	Interleukin-23 receptor
Protein Family:	Interleukin-23 receptor
UniProt Gene Name:	IL23R
UniProt Entry Name:	IL23R_HUMAN

	Western blot analysis of extracts of HeLa cells, using IL23R antibody (CAB1613) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded Mouse kidney using IL23R Rabbit pAb (CAB1613) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded Rat kidney using IL23R Rabbit pAb (CAB1613) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded Human thyroid cancer using IL23R Rabbit pAb (CAB1613) at dilution of 1:100 (40x lens).
	Immunofluorescence analysis of L929 cells using IL23R Rabbit pAb (CAB1613) at dilution of 1:100. Blue: DAPI for nuclear staining.