Cell Biology Antibodies 11
Anti-IL-22RA2 Antibody (CAB7145)
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- SKU:
- CAB7145
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL22RA2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB7145 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-231 of human IL22RA2 (NP_851826.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse spleen, Mouse lung, Rat spleen, Rat brain, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-231 of human IL22RA2 (NP_851826.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TQST HESL KPQR VQFQ SRNF HNIL QWQP GRAL TGNS SVYF VQYK IYGQ RQWK NKED CWGT QELS CDLT SETS DIQE PYYG RVRA ASAG SYSE WSMT PRFT PWWE TKID PPVM NITQ VNGS LLVI LHAP NLPY RYQK EKNV SIED YYEL LYRV FIIN NSLE KEQK VYEG AHRA VEIE ALTP HSSY CVVA EIYQ PMLD RRSQ RSEE RCVE IP |
| Gene ID: | 116379 |
| Uniprot: | Q969J5 |
| Cellular Location: | Secreted |
| Calculated MW: | 15kDa/26kDa/30kDa |
| Observed MW: | 31kDa |
| Synonyms: | IL22RA2, CRF2-10, CRF2-S1, CRF2X, IL-22BP, IL-22R-alpha-2, IL-22RA2, ZCYTOR16 |
| Background: | This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | IL22RA2: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 6q23.3 Cellular Component: extracellular space; plasma membrane; integral to membrane; cytosol Molecular Function:interleukin-22 binding; interleukin-22 receptor activity Biological Process: negative regulation of inflammatory response; cytokine and chemokine mediated signaling pathway; regulation of tyrosine phosphorylation of Stat3 protein |
| NCBI Summary: | This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q969J5 |
| NCBI GenInfo Identifier: | 61213728 |
| NCBI Gene ID: | 116379 |
| NCBI Accession: | Q969J5.1 |
| UniProt Secondary Accession: | Q969J5,Q08AH7, Q6UWM1, Q96A41, Q96QR0, |
| UniProt Related Accession: | Q969J5 |
| Molecular Weight: | 263 |
| NCBI Full Name: | Interleukin-22 receptor subunit alpha-2 |
| NCBI Synonym Full Names: | interleukin 22 receptor, alpha 2 |
| NCBI Official Symbol: | IL22RA2 |
| NCBI Official Synonym Symbols: | CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2 |
| NCBI Protein Information: | interleukin-22 receptor subunit alpha-2; interleukin 22-binding protein; cytokine receptor class-II member 10; cytokine receptor family type 2, soluble 1 |
| UniProt Protein Name: | Interleukin-22 receptor subunit alpha-2 |
| UniProt Synonym Protein Names: | Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor family type 2, soluble 1; CRF2-S1; Interleukin-22-binding protein; IL-22BP; IL22BP; ZcytoR16 |
| Protein Family: | Interleukin-22 receptor |
| UniProt Gene Name: | IL22RA2 |
| UniProt Entry Name: | I22R2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL22RA2 antibody (CAB7145) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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