Cell Biology Antibodies 2
Anti-IL-22RA1 Antibody (CAB10941)
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- SKU:
- CAB10941
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL22RA1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB10941 |
| Antibody Size: | 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human IL22RA1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human |
| Positive Samples: | K-562, U-87MG, HepG2, 293T |
| Immunogen: | A synthetic peptide of human IL22RA1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 58985 |
| Uniprot: | Q8N6P7 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 63kDa |
| Observed MW: | 80kDa |
| Synonyms: | IL22RA1, CRF2-9, IL22R, IL22R1 |
| Background: | The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. |
| UniProt Protein Function: | IL22RA1: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. Belongs to the type II cytokine receptor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: plasma membrane; integral to membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interferon receptor activity; interleukin-20 binding Biological Process: cytokine and chemokine mediated signaling pathway; defense response to Gram-negative bacterium |
| NCBI Summary: | The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N6P7 |
| NCBI GenInfo Identifier: | 74751067 |
| NCBI Gene ID: | 58985 |
| NCBI Accession: | Q8N6P7.1 |
| UniProt Secondary Accession: | Q8N6P7,Q9HB22, A8K839, B2R9Y9, |
| UniProt Related Accession: | Q8N6P7 |
| Molecular Weight: | 63,077 Da |
| NCBI Full Name: | Interleukin-22 receptor subunit alpha-1 |
| NCBI Synonym Full Names: | interleukin 22 receptor, alpha 1 |
| NCBI Official Symbol: | IL22RA1 |
| NCBI Official Synonym Symbols: | IL22R; CRF2-9; IL22R1 |
| NCBI Protein Information: | interleukin-22 receptor subunit alpha-1; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; cytokine receptor class-II member 9; cytokine receptor family 2 member 9; zcytoR11 |
| UniProt Protein Name: | Interleukin-22 receptor subunit alpha-1 |
| UniProt Synonym Protein Names: | Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; CRF2-9; ZcytoR11 |
| Protein Family: | Interleukin-22 receptor |
| UniProt Gene Name: | IL22RA1 |
| UniProt Entry Name: | I22R1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL22RA1 antibody (CAB10941) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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