Cell Biology Antibodies 10
Anti-IL-20 Antibody (CAB6629)
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- SKU:
- CAB6629
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL20 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB6629 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-176 of human IL20 (NP_061194.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-176 of human IL20 (NP_061194.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LKTL NLGS CVIA TNLQ EIRN GFSE IRGS VQAK DGNI DIRI LRRT ESLQ DTKP ANRC CLLR HLLR LYLD RVFK NYQT PDHY TLRK ISSL ANSF LTIK KDLR LCHA HMTC HCGE EAMK KYSQ ILSH FEKL EPQA AVVK ALGE LDIL LQWM EETE |
| Gene ID: | 50604 |
| Uniprot: | Q9NYY1 |
| Cellular Location: | Secreted |
| Calculated MW: | 17kDa/20kDa |
| Observed MW: | 20kDa |
| Synonyms: | IL20, IL-20, IL10D, ZCYTO10 |
| Background: | The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. |
| UniProt Protein Function: | IL20: Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3. Belongs to the IL-10 family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Cytokine; Secreted Chromosomal Location of Human Ortholog: 1q32 Cellular Component: extracellular space; extracellular region Molecular Function:interleukin-20 receptor binding; cytokine activity; interleukin-22 receptor binding Biological Process: positive regulation of osteoclast differentiation; regulation of inflammatory response; positive regulation of epidermal cell differentiation; positive regulation of JAK-STAT cascade; immune response; inflammatory response; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of keratinocyte differentiation |
| NCBI Summary: | The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NYY1 |
| NCBI GenInfo Identifier: | 38258955 |
| NCBI Gene ID: | 50604 |
| NCBI Accession: | Q9NYY1.2 |
| UniProt Secondary Accession: | Q9NYY1,Q17RB3, Q2THG6, Q96QZ6, |
| UniProt Related Accession: | Q9NYY1 |
| Molecular Weight: | 176 |
| NCBI Full Name: | Interleukin-20 |
| NCBI Synonym Full Names: | interleukin 20 |
| NCBI Official Symbol: | IL20 |
| NCBI Official Synonym Symbols: | IL-20; IL10D; ZCYTO10 |
| NCBI Protein Information: | interleukin-20; cytokine Zcyto10; four alpha helix cytokine |
| UniProt Protein Name: | Interleukin-20 |
| UniProt Synonym Protein Names: | Cytokine Zcyto10 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL20 |
| UniProt Entry Name: | IL20_HUMAN |
 | Western blot analysis of extracts of mouse liver, using IL20 Antibody (CAB6629) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver using IL20 antibody (CAB6629) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using IL20 antibody (CAB6629) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using IL20 antibody (CAB6629) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of A549 cells using IL20 antibody (CAB6629). Blue: DAPI for nuclear staining. |
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