Cell Biology Antibodies 7
Anti-IL-1RL1 Antibody (CAB1913)
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- SKU:
- CAB1913
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL1RL1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB1913 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-328 of human IL1RL1 (NP_003847.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-328 of human IL1RL1 (NP_003847.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KFSK QSWG LENE ALIV RCPR QGKP SYTV DWYY SQTN KSIP TQER NRVF ASGQ LLKF LPAA VADS GIYT CIVR SPTF NRTG YANV TIYK KQSD CNVP DYLM YSTV SGSE KNSK IYCP TIDL YNWT APLE WFKN CQAL QGSR YRAH KSFL VIDN VMTE DAGD YTCK FIHN ENGA NYSV TATR SFTV KDEQ GFSL FPVI GAPA QNEI KEVE IGKN ANLT CSAC FGKG TQFL AAVL WQLN GTKI TDFG EPRI QQEE GQNQ SFSN GLAC LDMV LRIA DVKE EDLL LQYD CLAL NLHG LRRH TVRL SRKN PSKE CF |
| Gene ID: | 9173 |
| Uniprot: | Q01638 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 23kDa/29kDa/36kDa/63kDa |
| Observed MW: | 30kDa/41kDa |
| Synonyms: | IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1 |
| Background: | The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | IL1RL1: receptor for IL33. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of ERK1 and/or ERK2, p38-alpha, and JNK1. Apparently promotes the activation and differentiation of T-helper 2 cells. Belongs to the interleukin-1 receptor family. Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Three isoforms of the human protein are produced by alternative splicing. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 2q12 Cellular Component: extracellular matrix; integral to membrane; extracellular region; external side of plasma membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; receptor signaling protein activity; interleukin-1 receptor activity Biological Process: negative regulation of T-helper 1 type immune response; negative regulation of interferon-gamma production; immune response; negative regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction; positive regulation of interleukin-5 production; positive regulation of inflammatory response; positive regulation of macrophage activation |
| NCBI Summary: | The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q01638 |
| NCBI GenInfo Identifier: | 116242527 |
| NCBI Gene ID: | 9173 |
| NCBI Accession: | Q01638.4 |
| UniProt Secondary Accession: | Q01638,Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44, A8K6B3, B4E0I3 |
| UniProt Related Accession: | Q01638 |
| Molecular Weight: | 23,723 Da |
| NCBI Full Name: | Interleukin-1 receptor-like 1 |
| NCBI Synonym Full Names: | interleukin 1 receptor-like 1 |
| NCBI Official Symbol: | IL1RL1 |
| NCBI Official Synonym Symbols: | T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R |
| NCBI Protein Information: | interleukin-1 receptor-like 1; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed |
| UniProt Protein Name: | Interleukin-1 receptor-like 1 |
| UniProt Synonym Protein Names: | Protein ST2 |
| Protein Family: | Interleukin-1 receptor |
| UniProt Gene Name: | IL1RL1 |
| UniProt Entry Name: | ILRL1_HUMAN |
 | Western blot analysis of extracts of mouse brain, using IL1RL1 antibody (CAB1913). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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