Cell Biology Antibodies 7
Anti-IL-1R2 Antibody (CAB1899)
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- SKU:
- CAB1899
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL1R2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB1899 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human IL1R2 (NP_775465.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Raji, DU145, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human IL1R2 (NP_775465.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AHTG AARS CRFR GRHY KREF RLEG EPVA LRCP QVPY WLWA SVSP RINL TWHK NDSA RTVP GEEE TRMW AQDG ALWL LPAL QEDS GTYV CTTR NASY CDKM SIEL RVFE NTDA FLPF ISYP QILT LSTS GVLV CPDL SEFT RDKT DVKI QWYK DSLL LDKD NEKF LSVR GTTH LLVH DVAL EDAG YYRC VLTF AHEG QQYN ITRS IELR IKKK KEET IPVI ISPL KTIS ASLG SRLT IPCK VFLG TGTP LTTM LWWT ANDT HIES AYPG GRVT EGPR QEYS ENNE NYIE VPLI FDPV TRED L |
| Gene ID: | 7850 |
| Uniprot: | P27930 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 33kDa/45kDa |
| Observed MW: | 36kDa |
| Synonyms: | IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB |
| Background: | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. |
| UniProt Protein Function: | IL-1RB: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Belongs to the interleukin-1 receptor family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 2q12 Cellular Component: plasma membrane Molecular Function:interleukin-1 receptor activity; protein binding Biological Process: immune response |
| NCBI Summary: | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012] |
| UniProt Code: | P27930 |
| NCBI GenInfo Identifier: | 124310 |
| NCBI Gene ID: | 7850 |
| NCBI Accession: | P27930.1 |
| UniProt Secondary Accession: | P27930,Q6LCE6, Q9UE68, D3DVJ5, |
| UniProt Related Accession: | P27930 |
| Molecular Weight: | 33,622 Da |
| NCBI Full Name: | Interleukin-1 receptor type 2 |
| NCBI Synonym Full Names: | interleukin 1 receptor type 2 |
| NCBI Official Symbol: | IL1R2 |
| NCBI Official Synonym Symbols: | IL1RB; CD121b; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2 |
| NCBI Protein Information: | interleukin-1 receptor type 2 |
| UniProt Protein Name: | Interleukin-1 receptor type 2 |
| UniProt Synonym Protein Names: | CD121 antigen-like family member B; CDw121b; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta |
| Protein Family: | Interleukin-1 receptor |
| UniProt Gene Name: | IL1R2 |
| UniProt Entry Name: | IL1R2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL1R2 antibody (CAB1899) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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