Immunology Antibodies 2
Anti-IL-1R1 Antibody (CAB5727)
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- SKU:
- CAB5727
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | IL1R1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB5727 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human IL1R1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, HeLa |
| Immunogen: | Recombinant protein of human IL1R1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3554 |
| Uniprot: | P14778 |
| Cellular Location: | Cell membrane, Membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 65kDa |
| Observed MW: | 80kDa |
| Synonyms: | IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80 |
| Background: | This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. |
| UniProt Protein Function: | IL-1RA: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Belongs to the interleukin-1 receptor family. |
| UniProt Protein Details: | Protein type:EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 2q12 Cellular Component: integral to plasma membrane; membrane; plasma membrane Molecular Function:interleukin-1 receptor activity; platelet-derived growth factor receptor binding; protein binding; signal transducer activity; transmembrane receptor activity Biological Process: cell surface receptor linked signal transduction; immune response |
| NCBI Summary: | This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013] |
| UniProt Code: | P14778 |
| NCBI GenInfo Identifier: | 124308 |
| NCBI Gene ID: | 3554 |
| NCBI Accession: | P14778.1 |
| UniProt Secondary Accession: | P14778,Q587I7, |
| UniProt Related Accession: | P14778 |
| Molecular Weight: | 65,402 Da |
| NCBI Full Name: | Interleukin-1 receptor type 1 |
| NCBI Synonym Full Names: | interleukin 1 receptor type 1 |
| NCBI Official Symbol: | IL1R1 |
| NCBI Official Synonym Symbols: | P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha |
| NCBI Protein Information: | interleukin-1 receptor type 1 |
| UniProt Protein Name: | Interleukin-1 receptor type 1 |
| UniProt Synonym Protein Names: | CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha |
| Protein Family: | Interleukin-1 receptor |
| UniProt Gene Name: | IL1R1 |
| UniProt Entry Name: | IL1R1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL1R1 antibody (CAB5727) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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