Cell Biology Antibodies 10
Anti-IL-18BP Antibody (CAB6445)
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- SKU:
- CAB6445
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL18BP Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB6445 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-194 of human IL18BP (NP_001138529.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-937, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-194 of human IL18BP (NP_001138529.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TPVS QTTT AATA SVRS TKDP CPSQ PPVF PAAK QCPA LEVT WPEV EVPL NGTL SLSC VACS RFPN FSIL YWLG NGSF IEHL PGRL WEGS TSRE RGST GTQL CKAL VLEQ LTPA LHST NFSC VLVD PEQV VQRH VVLA QLWA GLRA TLPP TQEA LPSS HSSP QQQG |
| Gene ID: | 10068 |
| Uniprot: | O95998 |
| Cellular Location: | Secreted |
| Calculated MW: | 12kDa/17kDa/21kDa |
| Observed MW: | 38kDa |
| Synonyms: | IL18BP, IL18BPa |
| Background: | The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | IL18BP: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q13 Cellular Component: extracellular space; extracellular region Molecular Function:receptor antagonist activity; interleukin-18 binding Biological Process: T-helper 1 type immune response; response to lipopolysaccharide |
| NCBI Summary: | The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] |
| UniProt Code: | O95998 |
| NCBI GenInfo Identifier: | 251757286 |
| NCBI Gene ID: | 10068 |
| NCBI Accession: | O95998.2 |
| UniProt Secondary Accession: | O95998,O95993, O96027, Q9NZA9, Q9UBR7, B3KUZ0, B7WPK4 |
| UniProt Related Accession: | O95998 |
| Molecular Weight: | 17,478 Da |
| NCBI Full Name: | Interleukin-18-binding protein |
| NCBI Synonym Full Names: | interleukin 18 binding protein |
| NCBI Official Symbol: | IL18BP |
| NCBI Official Synonym Symbols: | IL18BPa |
| NCBI Protein Information: | interleukin-18-binding protein; IL-18BP; MC51L-53L-54L homolog gene product; tadekinig-alfa |
| UniProt Protein Name: | Interleukin-18-binding protein |
| UniProt Synonym Protein Names: | Tadekinig-alfa |
| Protein Family: | Interleukin-18-binding protein |
| UniProt Gene Name: | IL18BP |
| UniProt Entry Name: | I18BP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL18BP antibody (CAB6445) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse heart using IL18BP antibody (CAB6445) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of A549 cells using IL18BP antibody (CAB6445). Blue: DAPI for nuclear staining. |
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