| UniProt Protein Function: | IL18: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Belongs to the IL-1 family. |
| UniProt Protein Details: | Protein type:Cytokine Chromosomal Location of Human Ortholog: 11q22.2-q22.3 Cellular Component: extracellular space; extracellular region; cytosol Molecular Function:protein binding; cytokine activity Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of NK T cell proliferation; natural killer cell activation; positive regulation of NF-kappaB import into nucleus; positive regulation of activated T cell proliferation; chemokine biosynthetic process; cell-cell signaling; lipopolysaccharide-mediated signaling pathway; granulocyte macrophage colony-stimulating factor biosynthetic process; angiogenesis; inflammatory response; positive regulation of interleukin-17 production; regulation of cell adhesion; positive regulation of natural killer cell proliferation; T-helper 1 type immune response; T-helper 2 type immune response; interleukin-2 biosynthetic process; MAPKKK cascade; interleukin-13 biosynthetic process; sleep; positive regulation of tissue remodeling; positive regulation of interferon-gamma production; interferon-gamma biosynthetic process; immune response; negative regulation of myoblast differentiation; positive regulation of inflammatory response |
| NCBI Summary: | The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011] |
| UniProt Code: | Q14116 |
| NCBI GenInfo Identifier: | 3219817 |
| NCBI Gene ID: | 3606 |
| NCBI Accession: | Q14116.1 |
| UniProt Secondary Accession: | Q14116,O75599, Q6FGY3, Q6WWJ7, |
| UniProt Related Accession: | Q14116 |
| Molecular Weight: | 21,896 Da |
| NCBI Full Name: | Interleukin-18 |
| NCBI Synonym Full Names: | interleukin 18 |
| NCBI Official Symbol: | IL18 |
| NCBI Official Synonym Symbols: | IGIF; IL-18; IL-1g; IL1F4 |
| NCBI Protein Information: | interleukin-18; IL-1 gamma; iboctadekin; interleukin-1 gamma; IFN-gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor) |
| UniProt Protein Name: | Interleukin-18 |
| UniProt Synonym Protein Names: | Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL18 |
| UniProt Entry Name: | IL18_HUMAN |
![Anti-IL-18 Antibody (CAB1115)[KO Validated]](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/39071/43817/anti-il-18-antibody-cab1115ko-validated__44856__80990.1706521194.jpg?c=1 "Anti-IL-18 Antibody (CAB1115)[KO Validated]")
