Cell Biology Antibodies 1
Anti-IL-17RA Antibody (CAB10052)
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- SKU:
- CAB10052
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL17RA Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB10052 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 697-866 of human IL17RA (NP_055154.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:4000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, Mouse liver, Mouse kidney, Mouse lung, Mouse thymus, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 697-866 of human IL17RA (NP_055154.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AGEG EACP LLGS PGAG RNSV LFLP VDPE DSPL GSST PMAS PDLL PEDV REHL EGLM LSLF EQSL SCQA QGGC SRPA MVLT DPHT PYEE EQRQ SVQS DQGY ISRS SPQP PEGL TEME EEEE EEQD PGKP ALPL SPED LESL RSLQ RQLL FRQL QKNS GWDT MGSE SEGP SA |
| Gene ID: | 23765 |
| Uniprot: | Q96F46 |
| Cellular Location: | Membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 92kDa/96kDa |
| Observed MW: | 100kDa |
| Synonyms: | IL17RA, CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R |
| Background: | Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971). |
| NCBI Summary: | Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014] |
| UniProt Code: | Q96F46 |
| NCBI GenInfo Identifier: | 116242517 |
| NCBI Gene ID: | 23765 |
| NCBI Accession: | Q96F46.2 |
| UniProt Secondary Accession: | Q96F46,O43844, Q20WK1, |
| UniProt Related Accession: | Q96F46 |
| Molecular Weight: | 92,153 Da |
| NCBI Full Name: | Interleukin-17 receptor A |
| NCBI Synonym Full Names: | interleukin 17 receptor A |
| NCBI Official Symbol: | IL17RA |
| NCBI Official Synonym Symbols: | CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R |
| NCBI Protein Information: | interleukin-17 receptor A |
| UniProt Protein Name: | Interleukin-17 receptor A |
| UniProt Synonym Protein Names: | CDw217; CD_antigen: CD217 |
| Protein Family: | Interleukin-17 receptor |
| UniProt Gene Name: | IL17RA |
 | Western blot analysis of extracts of various cell lines, using IL17RA antibody (CAB10052) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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