Cell Biology Antibodies 10
Anti-IL-17F Antibody (CAB6487)
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- SKU:
- CAB6487
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL17F Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB6487 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-163 of human IL17F (NP_443104.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | K-562, U-87MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-163 of human IL17F (NP_443104.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RKIP KVGH TFFQ KPES CPPV PGGS MKLD IGII NENQ RVSM SRNI ESRS TSPW NYTV TWDP NRYP SEVV QAQC RNLG CINA QGKE DISM NSVP IQQE TLVV RRKH QGCS VSFQ LEKV LVTV GCTC VTPV IHHV Q |
| Gene ID: | 112744 |
| Uniprot: | Q96PD4 |
| Cellular Location: | Secreted |
| Calculated MW: | 18kDa |
| Observed MW: | 18kDa |
| Synonyms: | IL17F, CANDF6, IL-17F, ML-1, ML1 |
| Background: | The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. |
| UniProt Protein Function: | Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation. |
| NCBI Summary: | The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96PD4 |
| NCBI GenInfo Identifier: | 239938888 |
| NCBI Gene ID: | 112744 |
| NCBI Accession: | Q96PD4.3 |
| UniProt Secondary Accession: | Q96PD4,Q6NSI0, Q7Z6P4, Q96PI8, Q9NUE6, |
| UniProt Related Accession: | Q96PD4 |
| Molecular Weight: | 18,045 Da |
| NCBI Full Name: | Interleukin-17F |
| NCBI Synonym Full Names: | interleukin 17F |
| NCBI Official Symbol: | IL17F |
| NCBI Official Synonym Symbols: | ML1; ML-1; CANDF6; IL-17F |
| NCBI Protein Information: | interleukin-17F |
| UniProt Protein Name: | Interleukin-17F |
| UniProt Synonym Protein Names: | Cytokine ML-1 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL17F |
 | Western blot analysis of extracts of various cell lines, using IL17F antibody (CAB6487) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunofluorescence analysis of MCF7 cells using IL17F antibody (CAB6487). Blue: DAPI for nuclear staining. |
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