Cell Biology Antibodies 17

Anti-IL-17A Receptor Antibody (CAB5163)

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SKU:
CAB5163
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-IL-17A Receptor Antibody
Antibody SKU:CAB5163
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human IL17A Receptor
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse lung, Rat kidney
Immunogen:A synthesized peptide derived from human IL17A Receptor
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23765
Uniprot:Q96F46
Cellular Location:
Calculated MW:160kDa
Observed MW:120KDa
Synonyms:CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R
Background:Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
UniProt Protein Function:Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).
NCBI Summary:Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
UniProt Code:Q96F46
NCBI GenInfo Identifier:116242517
NCBI Gene ID:23765
NCBI Accession:Q96F46.2
UniProt Secondary Accession:Q96F46,O43844, Q20WK1,
UniProt Related Accession:Q96F46
Molecular Weight:92,153 Da
NCBI Full Name:Interleukin-17 receptor A
NCBI Synonym Full Names:interleukin 17 receptor A
NCBI Official Symbol:IL17RA  
NCBI Official Synonym Symbols:CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R  
NCBI Protein Information:interleukin-17 receptor A
UniProt Protein Name:Interleukin-17 receptor A
UniProt Synonym Protein Names:CDw217; CD_antigen: CD217
Protein Family:Interleukin-17 receptor
UniProt Gene Name:IL17RA  
Anti-IL-17A Receptor Rabbit Monoclonal Antibody (CAB5163)Western blot - IL-17A Receptor Rabbit mAb (CAB5163)
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