Antibody Name:	IL17A Rabbit Polyclonal Antibody
Antibody SKU:	CAB12454
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 24-155 of human IL17A (NP_002181.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 24-155 of human IL17A (NP_002181.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	GITI PRNP GCPN SEDK NFPR TVMV NLNI HNRN TNTN PKRS SDYY NRST SPWN LHRN EDPE RYPS VIWE AKCR HLGC INAD GNVD YHMN SVPI QQEI LVLR REPP HCPN SFRL EKIL VSVG CTCV TPIV HHVA
Gene ID:	3605
Uniprot:	Q16552
Cellular Location:	Secreted
Calculated MW:	17kDa
Observed MW:

Synonyms:

IL17A, CTLA-8, CTLA8, IL-17, IL-17A, IL17

Background:

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

UniProt Protein Function:	IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.
UniProt Protein Details:	Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 6p12 Cellular Component: extracellular space; external side of plasma membrane Molecular Function:cytokine activity Biological Process: cell death; cell-cell signaling; apoptosis; positive regulation of interleukin-23 production; positive regulation of osteoclast differentiation; protein amino acid glycosylation; positive regulation of transcription from RNA polymerase II promoter; immune response; inflammatory response
NCBI Summary:	The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
UniProt Code:	Q16552
NCBI GenInfo Identifier:	2498481
NCBI Gene ID:	3605
NCBI Accession:	Q16552.1
UniProt Secondary Accession:	Q16552,Q5T2P0,
UniProt Related Accession:	Q16552
Molecular Weight:	17,504 Da
NCBI Full Name:	Interleukin-17A
NCBI Synonym Full Names:	interleukin 17A
NCBI Official Symbol:	IL17A
NCBI Official Synonym Symbols:	IL17; CTLA8; IL-17; IL-17A
NCBI Protein Information:	interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
UniProt Protein Name:	Interleukin-17A
UniProt Synonym Protein Names:	Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
Protein Family:	Interleukin
UniProt Gene Name:	IL17A
UniProt Entry Name:	IL17_HUMAN

	Immunohistochemistry of paraffin-embedded mouse kidney using IL17A antibody (CAB12454) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded rat kidney using IL17A antibody (CAB12454) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human stomach using IL17A antibody (CAB12454) at dilution of 1:100 (40x lens).