Cell Biology Antibodies 7
Anti-IL-16 Antibody (CAB1764)
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- SKU:
- CAB1764
Description
| Antibody Name: | IL16 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB1764 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-305 of human IL16 (NP_757366.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-305 of human IL16 (NP_757366.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MESH SRAG KSRK SAKF RSIS RSLM LCNA KTSD DGSS PDEK YPDP FEIS LAQG KEGI FHSS VQLA DTSE AGPS SVPD LALA SEAA QLQA AGND RGKT CRRI FFMK ESST ASSR EKPG KLEA QSSN FLFP KACH QRAR SNST SVNP YCTR EIDF PMTK KSAA PTDR QPYS LCSN RKSL SQQL DCPA GKAA GTSR PTRS LSTA QLVQ PSGG LQAS VISN IVLM KGQA KGLG FSIV GGKD SIYG PIGI YVKT IFAG GAAA ADGR LQEG DEIL ELNG ESMA GLTH QDAL QKFK QAKK GLLT LTVR TRLT A |
| Gene ID: | 3603 |
| Uniprot: | Q14005 |
| Cellular Location: | Cytoplasm, Nucleus, Secreted |
| Calculated MW: | 59kDa/66kDa/141kDa |
| Observed MW: | 142KDa |
| Synonyms: | IL16, LCF, NIL16, PRIL16, prIL-16 |
| Background: | The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | IL16: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. 3 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Cytokine; Motility/polarity/chemotaxis; DNA-binding Chromosomal Location of Human Ortholog: 15q26.3 Cellular Component: extracellular space; cytoplasm; plasma membrane; nucleus Molecular Function:cytokine activity Biological Process: viral reproduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; leukocyte chemotaxis; immune response; induction of positive chemotaxis |
| NCBI Summary: | The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
| UniProt Code: | Q14005 |
| NCBI GenInfo Identifier: | 239938922 |
| NCBI Gene ID: | 3603 |
| NCBI Accession: | Q14005.4 |
| UniProt Secondary Accession: | Q14005,Q16435, Q6VVE6, Q6ZMQ7, Q9UP18, A6NM20, A8MU65 B9EGR6, |
| UniProt Related Accession: | Q14005 |
| Molecular Weight: | 66,646 Da |
| NCBI Full Name: | Pro-interleukin-16 |
| NCBI Synonym Full Names: | interleukin 16 |
| NCBI Official Symbol: | IL16 |
| NCBI Official Synonym Symbols: | LCF; NIL16; PRIL16; prIL-16 |
| NCBI Protein Information: | pro-interleukin-16; prointerleukin 16; neuronal interleukin 16; lymphocyte chemoattractant factor |
| UniProt Protein Name: | Pro-interleukin-16 |
| UniProt Synonym Protein Names: | Lymphocyte chemoattractant factor; LCF |
| Protein Family: | Pro-interleukin |
| UniProt Gene Name: | IL16 |
| UniProt Entry Name: | IL16_HUMAN |
 | Western blot analysis of extracts of HepG2 cells, using IL16 Rabbit pAb (CAB1764) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using IL16 antibody (CAB1764). Blue: DAPI for nuclear staining. |
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Additional Information
Product Type: |
Antibody |
Reactivity: |
Human |
Reactivity: |
Mouse |
Host Species: |
Rabbit |
Isotype: |
IgG |
Antibody Type: |
Polyclonal Antibody |
Research Area: |
Cell Biology |
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