Cell Biology Antibodies 8
Anti-IL-13RA2 Antibody (CAB2043)
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- SKU:
- CAB2043
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL13RA2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB2043 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-343 of human IL13RA2 (NP_000631.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse spleen, Mouse liver, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-343 of human IL13RA2 (NP_000631.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DTEI KVNP PQDF EIVD PGYL GYLY LQWQ PPLS LDHF KECT VEYE LKYR NIGS ETWK TIIT KNLH YKDG FDLN KGIE AKIH TLLP WQCT NGSE VQSS WAET TYWI SPQG IPET KVQD MDCV YYNW QYLL CSWK PGIG VLLD TNYN LFYW YEGL DHAL QCVD YIKA DGQN IGCR FPYL EASD YKDF YICV NGSS ENKP IRSS YFTF QLQN IVKP LPPV YLTF TRES SCEI KLKW SIPL GPIP ARCF DYEI EIRE DDTT LVTA TVEN ETYT LKTT NETR QLCF VVRS KVNI YCSD DGIW SEWS DKQC WEGE DLSK KTLL R |
| Gene ID: | 3598 |
| Uniprot: | Q14627 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 44kDa |
| Observed MW: | 44kDa |
| Synonyms: | IL13RA2, CD213A2, CT19, IL-13R, IL13BP |
| Background: | The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. |
| UniProt Protein Function: | IL13RA2: a type I membrane protein that binds with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). Lacks a cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. Often overexpressed in brain tumors. A potential vaccine targets for immunotherapy of glioma. Note: This description may include information from RefSeq and UniProtKB |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cancer Testis Antigen (CTA); Receptor, cytokine Chromosomal Location of Human Ortholog: Xq23 Cellular Component: extracellular space; integral to membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; signal transducer activity Biological Process: cytokine and chemokine mediated signaling pathway; signal transduction |
| NCBI Summary: | The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14627 |
| NCBI GenInfo Identifier: | 2494720 |
| NCBI Gene ID: | 3598 |
| NCBI Accession: | Q14627.1 |
| UniProt Secondary Accession: | Q14627,O00667, A8K7E2, |
| UniProt Related Accession: | Q14627 |
| Molecular Weight: | 380 |
| NCBI Full Name: | Interleukin-13 receptor subunit alpha-2 |
| NCBI Synonym Full Names: | interleukin 13 receptor, alpha 2 |
| NCBI Official Symbol: | IL13RA2 |
| NCBI Official Synonym Symbols: | CT19; IL-13R; IL13BP; CD213A2 |
| NCBI Protein Information: | interleukin-13 receptor subunit alpha-2; IL-13RA2; IL-13R-alpha-2; IL-13R subunit alpha-2; cancer/testis antigen 19; IL-13 receptor subunit alpha-2; interleukin 13 binding protein; interleukin-13-binding protein; interleukin 13 receptor alpha 2 chain |
| UniProt Protein Name: | Interleukin-13 receptor subunit alpha-2 |
| UniProt Synonym Protein Names: | Interleukin-13-binding protein; CD_antigen: CD213a2 |
| Protein Family: | Interleukin-13 receptor |
| UniProt Gene Name: | IL13RA2 |
| UniProt Entry Name: | I13R2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL13RA2 antibody (CAB2043) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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